| Identification | Back Directory | [Name]
SABINENE | [CAS]
3387-41-5 | [Synonyms]
Sabinen
Sabenene
SABINENE
4-thujene
SABINENE(RG)
4(10)-Thujene
thuj-4(10)-ene
Sabinene (70%)
THUJENE, 4(10)-
NATURAL Sabinene
SABINENE WITH GC
SABINENE NATURAL
Sabinene Solution
Sabinene (beta-Thujene)
Bicyclo[3.1.0]hexane,4-met
RYANODINE(MIXTURE)(RG)(CALL)
2-Methylene-5-isopropylbicyclo[3.1.0]hexane
1-Isopropyl-4-methylenebicyclo[3.1.0]hexane
4-methylidene-1-propan-2-ylbicyclo[3.1.0]hexane
4-methylidene-1-propan-2-yl-bicyclo[3.1.0]hexane
4-methylene-1-(1-methylethyl)bicyclo[3.1.0]hexane
4-methylene-1-(1-methylethyl)-bicyclo[3.1.0]hexane
bicyclo[3.1.0]hexane,4-methylene-1-(1-methylethyl)-
sabinene,1-isopropyl-4-methylenebicyclo[3.1.0]hexane
1-isopropyl-4-methylenebicyclo[3.1.0]hexane (sabinene) | [EINECS(EC#)]
222-212-4 | [Molecular Formula]
C10H16 | [MDL Number]
MFCD00064917 | [MOL File]
3387-41-5.mol | [Molecular Weight]
136.23 |
| Chemical Properties | Back Directory | [Boiling point ]
163.7°C | [density ]
0.842 g/mL at 25 °C | [vapor pressure ]
87hPa at 20℃ | [refractive index ]
1.4860 (estimate) | [Fp ]
37℃ | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2)(1:2): 0.33 mg/ml | [form ]
A neat oil | [color ]
Colorless to light yellow | [Odor]
at 10.00 % in dipropylene glycol. woody terpene citrus pine spice | [Odor Type]
woody | [Water Solubility ]
5.03mg/L at 20℃ | [Major Application]
food and beverages | [InChI]
InChI=1S/C10H16/c1-7(2)10-5-4-8(3)9(10)6-10/h7,9H,3-6H2,1-2H3 | [InChIKey]
NDVASEGYNIMXJL-UHFFFAOYSA-N | [SMILES]
C(C12CCC(C1C2)=C)(C)C | [LogP]
5.5 at 25℃ |
| Hazard Information | Back Directory | [Description]
Sabinene is a bicyclic monoterpene found in a variety of plants, including Cannabis, that has antifungal and anti-inflammatory properties.1,2,3 It inhibits the growth of various fungi in vitro, including several species of Candida, Trichophyton, and Aspergillus (MICs = 0.16-5 μl/ml).3 Sabinene (0.32 μl/ml) prevents increases in nitrite production in RAW 264.7 macrophages stimulated by LPS and IFN-γ. It is cytotoxic to RAW 264.7 macrophages and HaCat keratinocytes when used at a concentration of 1.25 μl/ml. Formulations containing sabinene have been used as perfume additives. | [Uses]
Sabinene is an essential oil component, found to have bactericidal activity. | [Definition]
ChEBI: A thujene that is a bicyclic monoterpene isolated from the essential oils of various plant species. | [in vivo]
Sabinene (6.4 mg/kg; p.o.; once daily; during the fasting for 2 d) attenuates skeletal muscle atrophy by regulating the activation mechanism of ROS-mediated MAPK/MuRF-1 pathways in starved myotubes, probably leading to the reverse of reduced muscle fiber size in fasted rats[2].
| Animal Model: | Fasted animal model in rat[2] | | Dosage: | 6.4 mg/kg | | Administration: | Oral gavage; once daily; during the fasting for 2 days | | Result: | Reduced the levels of muscle fiber atrophy and MuRF-1 expression in gastrocnemius from fasted rats. |
| [References]
[1] YUJIN CAO. Biosynthesis and production of sabinene: current state and perspectives[J]. Applied Microbiology and Biotechnology, 2017, 102 4: 1535-1544. DOI: 10.1007/s00253-017-8695-5
[2] J. VALENTE . Antifungal, antioxidant and anti-inflammatory activities of Oenanthe crocata L. essential oil[J]. Food and Chemical Toxicology, 2013, 62: Pages 349-354. DOI: 10.1016/j.fct.2013.08.083 |
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