| Hazard Information | Back Directory | [Uses]
Treatment of transplant rejections; antipsoriatic (immunomodulator monoclonal antibody which decreases the activation, migration, and adhesion of T-cells). hu1124; anti-CD11a.
Efalizumab (Raptiva) is a humanized monoclonal antibody that binds to the CD11a subunit of LFA-1. It blocks the interaction of LFA-1 with ICAM-1, thereby interfering with T-cell activation and trafficking. Efalizumab is FDA approved at 1.0 mg/kg/week by subcutaneous injection. Common side effects include mild headache, fever, chills, nausea, or myalgia within the first 48 hours of injection in the first 2 to 3 weeks of therapy. Immune-mediated thrombocytopenia is rare. Worsening of psoriasis may occur after discontinuation of therapy or in unresponsive patients during therapy. Transitioning patients to alternative therapies may minimize this risk. | [Pharmacology]
Efalizumab (Raptiva) is a humanized monoclonal antibody that binds to the
CD11a subunit of LFA-1. It blocks the interaction of LFA-1 with ICAM-1,
thereby interfering with T-cell activation and trafficking. Efalizumab is FDA approved at 1.0 mg/kg/week by subcutaneous injection. | [Side effects]
Common side effects
include mild headache, fever, chills, nausea, or myalgia within the first 48
hours of injection in the first 2 to 3 weeks of therapy. Immune-mediated
thrombocytopenia is rare. Worsening of psoriasis may occur after discontinuation
of therapy or in unresponsive patients during therapy. Transitioning
patients to alternative therapies may minimize this risk. |
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