| Identification | Back Directory | [Name]
N-(4-Fluorophenyl)-4-phenyl-2-thiazolamine | [CAS]
339303-87-6 | [Synonyms]
GP130 receptor agonist-1
N-(4-Fluorophenyl)-4-phenyl-2-thiazolami
N-(4-Fluorophenyl)-4-phenylthiazol-2-amine
N-(4-Fluorophenyl)-4-phenyl-2-thiazolamine
2-Thiazolamine, N-(4-fluorophenyl)-4-phenyl-
GP130 receptor agonist-1,neuroprotective,Inhibitor,penetrant,NMDA,inhibit,GP-130 receptor agonist-1,brain,Interleukin Related,GP130 receptor agonist1,GP130,GP130 receptor agonist 1 | [Molecular Formula]
C15H11FN2S | [MDL Number]
MFCD00784992 | [MOL File]
339303-87-6.mol | [Molecular Weight]
270.32 |
| Hazard Information | Back Directory | [Uses]
N-(4-Fluorophenyl)-4-phenyl-1,3-thiazol-2-amine is a gp130 agonist. Protects against NMDA-induced toxicity in primary hippocampal neurons in vitro. Increases STAT3 phosphorylation in SH-SY5Y cells. Brain penetrant. | [in vivo]
For GP130 receptor agonist-1 (Compound 2), mice are dosed orally at 10 or 30 mg/kg, or injected subcutaneously (SQ) at 10 mg/kg, and euthanized after 1, 2, 4, 6, and 8 h post dose. At 2 h after SQ delivery at 10 mg/kg the brain Cmax is 161 ng/g while dosing at 30 mg/kg orally, results in the brain Cmax of 156 ng/g (0.57 μM). The brain to plasma ratio for 2 is ～4:1 for oral 30 mg/kg and ～7.5:1 for 10 mg/kg SQ injection[1]. | [storage]
Store at -20°C |
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| Company Name: |
Bide Pharmatech Ltd.
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| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
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