| Identification | Back Directory | [Name]
2-[(5-ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]-N-(furan-2-ylmethyl)acetamide | [CAS]
339337-07-4 | [Synonyms]
Primordazine B
Acetamide, 2-[(5-ethyl-5H-1,2,4-triazino[5,6-b]indol-3-yl)thio]-N-(2-furanylmethyl)-
2-[(5-ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]-N-(furan-2-ylmethyl)acetamide | [Molecular Formula]
C18H17N5O2S | [MOL File]
339337-07-4.mol | [Molecular Weight]
367.43 |
| Hazard Information | Back Directory | [Uses]
Primordazine B is a small molecule compound identified by chemical screening in zebrafish embryos with the activity of selectively destroying Primordial Germ Cells (PGCs). Primordazine B inhibits a process called Poly(A)-tail Independent Non-canonical Translation (PAINT) without inhibition of polyadenylate tail dependent typical translation (PAT). Primordazine B can be used to study translational control of cells in specific physiological or pathological states, such as gene expression regulation during cell dormancy, viral infection, or stress conditions[1]. | [References]
[1] Youngnam N Jin, et al. Noncanonical translation via deadenylated 3′ UTRs maintains primordial germ cells[J]. Nature chemical biology, 2018, 14(9): 844-852. DOI:10.1038/s41589-018-0098-0 |
|
|