| Identification | Back Directory | [Name]
3,3'-((4-Methoxyphenyl)Methylene)bis(1H-indole) | [CAS]
33985-68-1 | [Synonyms]
C-DIM5
DIM-C-pPhOCH3
DIM-C-pPhOCH3(C-DIM5)
DIM-C-pPhOCH3 >=98% (HPLC)
Bis(1H-indol-3-yl)(4-methoxyphenyl)]methane
1,1-bis(3′-Indolyl)-1-(p-methoxyphenyl)methane
3,3'-((4-Methoxyphenyl)Methylene)bis(1H-indole)
1H-Indole, 3,3'-[(4-methoxyphenyl)methylene]bis- | [EINECS(EC#)]
604-604-1 | [Molecular Formula]
C24H20N2O | [MDL Number]
MFCD01217840 | [MOL File]
33985-68-1.mol | [Molecular Weight]
352.43 |
| Chemical Properties | Back Directory | [Melting point ]
187-189 °C | [Boiling point ]
592.7±50.0 °C(Predicted) | [density ]
1.251±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: ≥30mg/mL | [form ]
powder | [pka]
16.63±0.30(Predicted) | [color ]
off-white to light yellow | [InChI]
1S/C24H20N2O/c1-27-17-12-10-16(11-13-17)24(20-14-25-22-8-4-2-6-18(20)22)21-15-26-23-9-5-3-7-19(21)23/h2-15,24-26H,1H3 | [InChIKey]
ZCCMKJAXOIFTHH-UHFFFAOYSA-N | [SMILES]
COc1ccc(cc1)C(c2c[nH]c3ccccc23)c4c[nH]c5ccccc45 |
| Hazard Information | Back Directory | [Uses]
[Bis(1H-indol-3-yl)(4-methoxyphenyl)]methane, is a Nur77 agonist. Nerve growth factor-induced Bα (NGFI-Bα, Nur77) is an orphan nuclear receptor. | [Biological Activity]
DIM-C-pPhOCH3 is a Nerve Growth Factor-Induced Bα (NGFI-BαNur77) agonist | [in vivo]
DIM-C-pPhOCH3 (25 mg/kg/d) also inhibits tumor growth in athymic nude mice bearing RKO cell xenografts. The effects of DIM-C-pPhOCH3 (25 mg/kg/d) on colon tumor growth are also investigated in athymic nude mice bearing RKO cell xenografts. Treatment with the DIM-C-pPhOCH3 significantly decreases tumor volumes and final tumor weights compared with corn oil controls[1]. | [IC 50]
Nur77/NR4A1 | [storage]
Store at -20°C |
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Rhawn Reagent
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400-400-1332688 18019345275 |
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http://www.rhawn.cn |
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