| Identification | Back Directory | [Name]
Tucotuzumab Celmoleukin | [CAS]
339986-90-2 | [Synonyms]
Tucotuzumab Celmoleukin
Research Grade Tucotuzumab (DHD17404) |
| Hazard Information | Back Directory | [Uses]
Tucotuzumab (Anti-EPCAM Recombinant Antibody) is an antigen-specific IgG1 monoclonal antibody that targets human epithelial cell adhesion molecule (EpCAM). Tucotuzumab links two IL-2 molecules and is an immunosuppressant and anti-tumor active molecule[1]. | [in vivo]
Tucotuzumab (75 μg; intratumoral injection; 5 daily of 15 μg (total dose of 75 μg), each in 50 μL PBS; on days 10 and 14) results in significantly greater tumor growth suppression and enhances survival[1]. | Animal Model: | Female Balb/c mice bearing CT26-KS colon adenocarcinoma[1] | | Dosage: | 75 μg | | Administration: | Intratumoral injection; 5 daily of 15 μg (total dose of 75 μg), each in 50 μL PBS; on days 10 and 14 | | Result: | Resulted in significantly greater tumor growth suppression and enhanced survival.
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| [References]
[1] Erik E Johnson, et al. Radiofrequency ablation combined with KS-IL2 immunocytokine (EMD 273066) results in an enhanced antitumor effect against murine colon adenocarcinoma. Clin Cancer Res. 2009 Aug 1;15(15):4875-84. DOI:10.1158/1078-0432.CCR-09-0110 |
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