| Identification | Back Directory | [Name]
1-[[(4-Nitrophenyl)methyl]sulfonyl]-pyrrolidine | [CAS]
340041-91-0 | [Synonyms]
AP-1
AH119
MFCD09952023
NF-κB (p49) human
C-jun, proto oncogene human
c-JUN (1-79), GST tagged human
Anti-FOS antibody produced in goat
1-((4-Nitrobenzyl)sulfonyl)pyrrolidine
4-(Pyrrolidino sulfonyl methyl)nitrobenzene
1-(4-Nitrophenylmethanesulfonyl)pyrrolidine
N-[(4-Nitrophenyl)-methylsulfonyl]pyryolidine
Monoclonal Anti-JUN antibody produced in mouse
FBJ murine osteosarcoma viral oncogene homolog
1-[[(4-nitrophenyl)methyl]sulfonyl]-pyrrolidine
N-[(4-Nitro Phenyl) Methyl sulfonyl] pyrrolidine
Pyrrolidine,1-[[(4-nitrophenyl)methyl]sulfonyl]-
Anti-C-JUN, C-Terminal antibody produced in rabbit
FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS) | [EINECS(EC#)]
608-939-3 | [Molecular Formula]
C11H14N2O4S | [MDL Number]
MFCD02095845 | [MOL File]
340041-91-0.mol | [Molecular Weight]
270.3 |
| Chemical Properties | Back Directory | [density ]
1.41 | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMF: 30 mg/ml
DMSO: 30 mg/ml | [form ]
frozen liquid | [color ]
clear
colorless | [biological source]
mouse |
| Hazard Information | Back Directory | [Uses]
cell analysis | [Biological Activity]
The transcription factor AP-1 (activator protein-1) is involved in cellular proliferationtransformation and death. AP-1 and nuclear factor B (NF- B) can be specifically targeted to prevent cancer induction in mouse models. AP-1 can be produced by 18 different dimeric combinations of proteins from the Jun (c-JunJunB and JunD) and Fos (c-FosFosBFra-1 and Fra-2) familiesincluding Jun homodimers and Jun-Fos heterodimers. The Jun and Fos proteins contain a basic-region leucine zipper (bZIP) domainand are capable of binding to other bZIP proteins including those from the ATFMAFCNC and C/EBP (CCAAT/enhancer-binding protein) subfamilies (5]) Jun-Jun and Jun-Fos dimers bind with highest affinity to the 12-O-tetradecanoylphorbol-13-acetate (TPA) response element (TRE) [TGA(C/G)TCA]although many other μAP-1-like sitesμ have been reported. Binding to any of these sites can be tissue-specificor affected by neighboring sequencesand dependent upon interactions with | [References]
[1] LIDONG GONG . Discovery of a miniaturized PROTAC with potent activity and high selectivity[J]. Bioorganic Chemistry, 2023, 136: Article 106556. DOI: 10.1016/j.bioorg.2023.106556 |
|
|