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341498-08-6

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341498-08-6 Structure

341498-08-6 Structure
IdentificationBack Directory
[Name]

N-succiniMidyl 4-(2-pyridyldithio)pentanoate
[CAS]

341498-08-6
[Synonyms]

N-succiniMidyl 4-(2-pyridyldithio)pentanoate
N-succinimidyl 4-(2-pyridyldithio)-pentanoate / SPP
4-(Pyridin-2-yldisulfanyl)pentanoic acid N-Hydroxy succinimide ester
[EINECS(EC#)]

636-474-6
[Molecular Formula]

C14H16N2O4S2
[MDL Number]

MFCD20230233
[MOL File]

341498-08-6.mol
[Molecular Weight]

340.42
Chemical PropertiesBack Directory
[Melting point ]

48-49 °C
[Boiling point ]

483.5±55.0 °C(Predicted)
[density ]

1.39±0.1 g/cm3(Predicted)
[form ]

Solid
[pka]

1.83±0.19(Predicted)
[color ]

Off-white to light yellow
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319-H335
[Precautionary statements ]

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501
Hazard InformationBack Directory
[Uses]

SPP (N-succinimidyl 4-(2-pyridyldithio) pentanoate) is a cleavable disulfide linker, can be used to form cytotoxic compound- linker conjugate[1].
[IC 50]

Cleavable Linker; Disulfide Cleavable Linker
[References]

[1] Widdison W, et al. Metabolites of antibody-maytansinoid conjugates: characteristics and in vitro potencies. Mol Pharm. 2015 Jun 1;12(6):1762-73. DOI:10.1021/mp5007757
Spectrum DetailBack Directory
[Spectrum Detail]

N-succiniMidyl 4-(2-pyridyldithio)pentanoate(341498-08-6)1HNMR
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