| Identification | Back Directory | [Name]
1-Phenazinecarboxamide, N,N'-[1,2-ethanediylbis(imino-2,1-ethanediyl)]bis[9-methyl- | [CAS]
343247-32-5 | [Synonyms]
MLN944
XR5944
XR-5944
MLN-944
XR 5944
MLN 944
1-Phenazinecarboxamide, N,N'-[1,2-ethanediylbis(imino-2,1-ethanediyl)]bis[9-methyl- | [Molecular Formula]
C34H34N8O2 | [MDL Number]
MFCD09833885 | [MOL File]
343247-32-5.mol | [Molecular Weight]
586.69 |
| Chemical Properties | Back Directory | [Melting point ]
243-245 °C(Solv: methanol (67-56-1)) | [Boiling point ]
948.7±65.0 °C(Predicted) | [density ]
1.284±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
12.47±0.46(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
XR5944 is an anti-tumor compound with DNA-targeting activity. As a topoisomerase inhibitor, XR5944 can effectively inhibit the activities of topoisomerase I and II. XR5944 shows excellent anti-tumor activity against human and mouse tumor cells in vitro and in vivo. XR5944 exhibits significant potency in multiple cell lines, with IC50 values of 0.04-0.4 nM. XR5944 is not affected by atypical drug resistance in cells and remains significantly active even in cells overexpressing P-glycoprotein or multidrug resistance-related proteins. XR5944 showed anti-tumor efficacy in human tumor models of H69 small cell lung cancer and HT29 colon cancer, inducing tumor regression in most animals in the HT29 model. XR5944 can be used to study biological processes related to colon and lung cancer[1]. | [References]
[1] Antitumor activity of XR5944, a novel and potent topoisomerase poison |
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