| Identification | Back Directory | [Name]
4-AMINO-1-N-BUTOXYCARBONYL-4-METHYL-PIPERIDINE | [CAS]
343788-69-2 | [Synonyms]
4-Amino-1-Boc-4-methylpip...
TERT-BUTYL-4-AMINO-4-METHYLPIP
1-Boc-4-AMino-4-Methylpiperidine
4-Amino-1-Boc-4-methylpiperidine
N-Boc-4-amino-4-methylpiperidine
1-BOC-4-AMINO-4-METHYL PIPERADINE
4-AMINO-4-METHYL-N-BOC-PIPERIDINE
4-AMINO-4-METHYL-1-BOC-PIPERIDINE
4-Amino-1-N-boc-4-methyl-piperidine
butyl 4-aMino-4-Methylpiperidine-1-carboxylate
4-AMINO-1-N-BUTOXYCARBONYL-4-METHYL-PIPERIDINE
1-(tert-Butoxycarbonyl)-4-amino-4-methylpiperidine
TERT-BUTYL 4-AMINO-4-METHYLPIPERIDINE-1-CARBOXYLATE
4-AMINO-1-N-TERT-BUTYLOXYCARBONYL-4-METHYL-PIPERIDINE
4-AMino-4-Methyl-1-piperidinecarboxylic acid tert-butyl ester
1-Piperidinecarboxylic acid, 4-aMino-4-Methyl-, 1,1-diMethylethyl ester | [EINECS(EC#)]
674-596-1 | [Molecular Formula]
C11H22N2O2 | [MDL Number]
MFCD03411925 | [MOL File]
343788-69-2.mol | [Molecular Weight]
214.3 |
| Chemical Properties | Back Directory | [Boiling point ]
283℃ | [density ]
1.017 | [Fp ]
125℃ | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [pka]
9.77±0.20(Predicted) | [Appearance]
Colorless to light yellow Solid-Liquid Mixture |
| Hazard Information | Back Directory | [Chemical Properties]
White powder | [Synthesis]
General procedure for the synthesis of tert-butyl 4-amino-4-methylpiperidine-1-carboxylate from the compound (CAS: 236406-14-7): a mixture of the compound of formula LE (2.48 g, 7.11 mmol) with 10% palladium carbon (200 mg, Sigma-Aldrich) in methanol (20 mL) was subjected to an atmosphere of hydrogen at about 250 °C The reaction was stirred for 16 hours. Upon completion of the reaction, the Pd/C catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to give 1.37 g of the compound of formula LF as a light-colored viscous oil (90.2% yield). The structure of tert-butyl 4-amino-4-methylpiperidine-1-carboxylate, compound of formula LF, was confirmed using 1H NMR. The 1H NMR data of compound LF were as follows: δH (400 MHz, CDCl3): 3.47-3.49 (4H, m), 1.47-1.61 (4H, m), 1.46 (9H, s), 1.31-1.42 (2H, m), 1.15 (3H, s). | [References]
[1] Patent: WO2008/89201, 2008, A2. Location in patent: Page/Page column 234-235
[2] Journal of Medicinal Chemistry, 2012, vol. 55, # 12, p. 5901 - 5921
[3] Patent: WO2006/38006, 2006, A2. Location in patent: Page/Page column 26-27
[4] Patent: WO2009/116067, 2009, A2. Location in patent: Page/Page column 139 |
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