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Sulcardine hydrochloride is a multi-ion channel blocker that can reduce INa and ICa with IC50 values of 26.9 μM and 69.2 μM, respectively. Sulcardine hydrochloride is a potent hNav1.5 channel blocker with a mild inhibitory effect on hERG channels. Sulcardine hydrochloride has anti-arrhythmic effects[1][2]. | [References]
[1] Bai
DL,et al. Discovery of
N-(3,5-bis(1-pyrrolidylmethyl)-4-hydroxybenzyl)-4-methoxybenzenesulfamide
(sulcardine) as a novel anti-arrhythmic agent. Acta Pharmacol Sin. 2012
Sep;33(9):1176-86. DOI:10.1038/aps.2012.119
[2] Chen W, et al. Characteristics of hERG and hNav1.5 channel blockade by sulcardine sulfate, a novel anti-arrhythmic compound. Eur J Pharmacol. 2019 Feb 5;844:130-138. DOI:10.1016/j.ejphar.2018.12.009 |
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