| Identification | Back Directory | [Name]
diphenylterazine | [CAS]
344940-63-2 | [Synonyms]
DTZ
diphenylterazine
Diphenylterazine (DTZ)
Imidazo[1,2-a]pyrazin-3(7H)-one, 6,8-diphenyl-2-(phenylmethyl)- | [Molecular Formula]
C25H19N3O | [MDL Number]
MFCD31619283 | [MOL File]
344940-63-2.mol | [Molecular Weight]
377.44 |
| Chemical Properties | Back Directory | [Boiling point ]
538.4±60.0 °C(Predicted) | [density ]
1.21±0.1 g/cm3(Predicted) | [solubility ]
DMSO:75.0(Max Conc. mg/mL);198.71(Max Conc. mM)
DMF:11.11(Max Conc. mg/mL);29.44(Max Conc. mM) | [form ]
A solid | [pka]
6.33±0.40(Predicted) | [color ]
Orange to reddish brown |
| Hazard Information | Back Directory | [Uses]
Diphenylterazine (DTZ) is a bioluminescence agent. Diphenylterazine alone yielded very little background, leading to excellent signal-to-background ratios[1]. | [in vivo]
Diphenylterazine injections into untransfected BALB/c mice do not yield any background emission. The bioluminescence resulting from intraperitoneally injected Diphenylterazine displays extended kinetics[1].
DTZ (0.3 μmol/mouse (1.13 mg.ml-1/100 ul/mouse); i.v.) treatment can track tumor growth in a xenograft NU/J mouse model[4]. | [References]
[1] Yeh HW, et al. Red-shifted luciferase-luciferin pairs for enhanced bioluminescence imaging. Nat Methods. 2017 Oct;14(10):971-974. DOI:10.1038/nmeth.4400
[2] Yeh AH, et al. De novo design of luciferases using deep learning. Nature. 2023 Feb;614(7949):774-780. DOI:10.1038/s41586-023-05696-3
[3] Practical Notes for teLuc-DTZ and Antares2-DTZ (updated 07/29/2019).
[4] Hsien-Wei Yeh, et al. ATP-Independent Bioluminescent Reporter Variants To Improve in Vivo Imaging. ACS Chem Biol. 2019 May 17;14(5):959-965. DOI:10.1021/acschembio.9b00150 |
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InvivoChem Gold
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13549236410 |
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https://www.invivochem.cn/ |
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