| Identification | Back Directory | [Name]
Cyclopentanecarboxylic acid, 3-[(1S)-1-(acetylamino)-2-propylpentyl]-4-[(aminoiminomethyl)amino]-, (1R,3S,4R)- | [CAS]
345267-14-3 | [Synonyms]
Cyclopentanecarboxylic acid, 3-[(1S)-1-(acetylamino)-2-propylpentyl]-4-[(aminoiminomethyl)amino]-, (1R,3S,4R)- | [Molecular Formula]
C17H32N4O3 | [MOL File]
345267-14-3.mol | [Molecular Weight]
340.46 |
| Hazard Information | Back Directory | [Uses]
BCX-1898, a cyclopentane derivative, is an orally active and selective influenza virus neuraminidase inhibitor. BCX-1898 has antiviral activity with EC50s of <0.01-21 μM on influenza A (H1N1, H3N2, and H5N1) and influenza B viruses replication in MDCK cells. BCX-1898 shows protection against the mouse influenza model[1][2]. | [in vivo]
BCX-1898 (1, 10 mg/kg/day; Oral; 22 days) shows complete protection against the influenza virus with 10 mg/kg/day[2].
BCX-1898 (0.01, 0.1 mg/kg/day; intranasal treatment; 20 days) demonstrates complete protection (10 out of 10 survived)[2].
| Animal Model: | Mice (13-18 g) infected with the A/Turkey/Mas/ 76 X A/Beijing/32/92 (H6N2) influenza virus[2] | | Dosage: | 1, 10 mg/kg/day | | Administration: | Oral; 22 days | | Result: | Showed complete protection against the influenza virus with 10 mg/kg/day, whereas at dose level (1 mg/kg/day) showed only a 10% protection against the influenza virus.
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| [References]
[1] D F Smee, et al. Cyclopentane neuraminidase inhibitors with potent in vitro anti-influenza virus activities. Antimicrob Agents Chemother. 2001 Mar;45(3):743-8. DOI:10.1128/AAC.45.3.743-748.2001
[2] Pooran Chand, et al. Comparison of the anti-influenza virus activity of cyclopentane derivatives with oseltamivir and zanamivir in vivo. Bioorg Med Chem. 2005 Jun 2;13(12):4071-7. DOI:10.1016/j.bmc.2005.03.048 |
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