| Identification | Back Directory | [Name]
AZD9056 (hydrochloride) | [CAS]
345303-91-5 | [Synonyms]
AZD-9056 HCl
AZD9056 (hydrochloride)
AZD-9056 HYDROCHLORIDE; AZD 9056 HYDROCHLORIDE
AZD9056 hydrochloride,AZD 9056,AZD-9056,P2X Receptor,P2XRs,Inhibitor,AZD-9056 hydrochloride,AZD9056,inhibit | [Molecular Formula]
C24H36Cl2N2O2 | [MDL Number]
MFCD30718168 | [MOL File]
345303-91-5.mol | [Molecular Weight]
455.46 |
| Hazard Information | Back Directory | [Uses]
AZD9056 hydrochloride is a selective orally active inhibitor of P2X7 which plays a significant role in inflammation and pain-causing diseases. | [in vivo]
Treatment with AZD9056 exerts pain-relieving and anti-inflammatory effects. The upregulated expression of interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), matrix metalloproteinase-13 (MMP-13), substance P (SP) and prostaglandin E2 (PGE2) which is induced by MIA in cartilage tissues is reversed by AZD9056[3]. | [IC 50]
P2X7 Receptor | [References]
[1] Seeland S, et al. ATP-induced cellular stress and mitochondrial toxicity in cells expressing purinergic P2X7 receptor. Pharmacol Res Perspect. 2015 Mar;3(2):e00123. DOI:10.1002/prp2.123
[2] Elsby R, et al. In vitro risk assessment of AZD9056 perpetrating a transporter-mediated drug-drug interaction with methotrexate. Eur J Pharm Sci. 2011 May 18;43(1-2):41-9. DOI:10.1016/j.ejps.2011.03.006
[3] Hu H, et al. Blocking of the P2X7 receptor inhibits the activation of the MMP-13 and NF-κB pathways in the cartilage tissue of rats with osteoarthritis. Int J Mol Med. 2016 Dec;38(6):1922-1932. DOI:10.3892/ijmm.2016.2770 |
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| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
| Company Name: |
Alomone Labs
|
| Tel: |
4008-168-068 13121892008 |
| Website: |
www.alomone.com |
|