345310-98-7

374795-58-1

345310-98-7

The general procedure for the synthesis of 1-(2-pyridyl)-piperazinone from the compound (CAS:374795-58-1) was as follows: a slurry of palladium carbon (5%, 3.6 g) in water was added to a solution of palladium carbon containing 4-phenylmethyl-1-(2-pyridyl)piperazin-2-one (3.6 g, 13.48 mmol) and ammonium formate (4.25 g, 67.5 mmol) in a in methanol (100 mL) solution. The mixture was heated to reflux for 4 hours and subsequently cooled to room temperature. The reaction mixture was filtered through a Hyflo TM and the filter cake was washed with methanol. The filtrate was concentrated under reduced pressure to remove the solvent and the resulting residue was purified by fast column chromatography on silica gel, using CH2Cl2/MeOH (90:10) as eluent, to give 1-(2-pyridyl)-piperazinone as an orange oil (1.1 g, 46% yield). Mass spectrometry analysis showed m/z (ES+) 178 ([M+1]+).