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3458-69-3

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3458-69-3 Structure

3458-69-3 Structure
IdentificationBack Directory
[Name]

HPCG
[CAS]

3458-69-3
[Synonyms]

HPCG
N-[(3-Hydroxy-2-pyridinyl)carbonyl]glycine
2-[(3-hydroxypyridin-2-yl)formamido]acetic acid
[Molecular Formula]

C8H8N2O4
[MDL Number]

MFCD00941661
[MOL File]

3458-69-3.mol
[Molecular Weight]

196.16
Chemical PropertiesBack Directory
[Boiling point ]

644.3±50.0 °C(Predicted)
[density ]

1.479±0.06 g/cm3(Predicted)
[pka]

4.48±0.35(Predicted)
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H335-H319-H315
[Precautionary statements ]

P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
Hazard InformationBack Directory
[Description]

HPCG is a HIF-1α prolyl hydroxylase inhibitor.
[Uses]

2-(3-Hydroxypicolinamido)acetic acid is a 2OG oxygenase inhibitor with an IC50 value of 3.4 μM. 2-(3-Hydroxypicolinamido)acetic acid can be used as a functional probe for potential therapeutic research[1].
[References]

[1] Woon EC, et al. Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase. J Med Chem. 2012 Mar 8;55(5):2173-84. DOI:10.1021/jm201417e
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