| Identification | Back Directory | [Name]
adenosine 5'-monophosphate, monoanhydride with (phosphonomethyl)phosphonic acid | [CAS]
3469-78-1 | [Synonyms]
AMP-P(CH2)P
β,γ-MethyleneATP
Einecs 222-435-7
β,γ-Methylene ATP
Adenylyl methylenediphosphonate
5'-adenylyl (beta,gamma-methylene)diphosphonate
5'-Adenylic acid (phosphonomethyl)phosphonyl ester
5'-Adenylic acid, monohydride with methylenebis(phosphonic acid)
adenosine 5'-monophosphate, monoanhydride with (phosphonomethyl)phosphonic acid | [EINECS(EC#)]
222-435-7 | [Molecular Formula]
C11H18N5O12P3 | [MDL Number]
MFCD05662223 | [MOL File]
3469-78-1.mol | [Molecular Weight]
505.21 |
| Hazard Information | Back Directory | [Uses]
AMP-PCP is an ATP analogue and can bind to Hsp90 N-terminal domain with a Kd value of 3.8 μM. AMP-PCP binding favors the formation of the active homodimer of Hsp90[1]. | [Definition]
ChEBI: Adenosine 5'-[beta,gamma-methylene]triphosphate is a nucleoside triphosphate analogue. | [IC 50]
HSP90: 3.8 μM (Kd) | [References]
[1] Zhang H, et al. A dynamic view of ATP-coupled functioning cycle of Hsp90 N-terminal domain. Sci Rep. 2015 Apr 13;5:9542. DOI:10.1038/srep09542 |
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