| Identification | Back Directory | [Name]
4-Methyl-3-[[4-[methyl(2-methylpropyl)amino]-6-[(3R)-3-pyrrolidinylamino]-1,3,5-triazin-2-yl]amino]benzamide | [CAS]
348089-57-6 | [Synonyms]
| [Molecular Formula]
C20H30N8O | [MOL File]
348089-57-6.mol | [Molecular Weight]
398.51 |
| Chemical Properties | Back Directory | [Boiling point ]
597.7±60.0 °C(Predicted) | [density ]
1.252±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [pka]
16.25±0.50(Predicted) |
| Hazard Information | Back Directory | [Uses]
PS-166276 is a highly potent and less cytotoxic inhibitor of p38. PS166276 has an IC50 of 28 nM at p38 kinase and 170 nM in the THP-1 TNFα assay[1]. | [in vivo]
PS166276 (30 mg/kg, s.c., mice) inhibits LPS-induced TNFα production in mice[1]. | [References]
[1] Tsung H Lin, et al. Discovery and characterization of triaminotriazine aniline amides as highly selective p38 kinase inhibitors. J Pharmacol Exp Ther. 2006 Aug;318(2):495-502. DOI:10.1124/jpet.105.097568 |
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