| Identification | Back Directory | [Name]
TRIMETHYLCOLCHICINIC ACID | [CAS]
3482-37-9 | [Synonyms]
NSC 36796
Aids002892
Aids-002892
Deacetylcolchiceine
Desacetylcolchiceine
deacetylcholchiceine
desacetylcholchiceine
n-deacetyl-colchicein
N-DEACETYLCOLCHICEINE
trimethyl-colchicinicaci
TRIMETHYLCOLCHICINIC ACID
7-amino-6,7-dihydro-10-hydroxy-1,2,3-trimethoxy-benzo(a)heptalen-9(5h)-on
(S)-7-amino-6,7-dihydro-10-hydroxy-1,2,3-trimethoxybenzo[a]heptalen-9(5H)-one
(7S)-7-AMino-6,7-dihydro-10-hydroxy-1,2,3-triMethoxy-benzo[a]heptalen-9(5H)-one | [EINECS(EC#)]
222-464-5 | [Molecular Formula]
C19H21NO5 | [MDL Number]
MFCD00082296 | [MOL File]
3482-37-9.mol | [Molecular Weight]
343.37 |
| Chemical Properties | Back Directory | [Appearance]
Yellow-green Solid | [Melting point ]
>230°C (dec.) | [Boiling point ]
478.65°C (rough estimate) | [density ]
1.2726 (rough estimate) | [refractive index ]
1.5000 (estimate) | [storage temp. ]
−20°C
| [solubility ]
Chloroform (Slightly, Sonicated), DMSO (Slightly), Ethanol (Slightly), Methanol | [form ]
Solid | [color ]
Pale Green to Yellow |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow-green Solid | [Uses]
An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway. | [Description]
A minor alkaloid of the colchicine class, this base was first isolated from the
seeds and corms of Colchicum autumnale, Gloriosa virescens and Littoria modesta
and subsequently by Russian workers from Merendera robusta Bge. Several
specific rotations have been measured, e.g. [α]D - 184°, - 152° and - 180°
(all in CHC13). The base is separated from the numerous accompanying alkaloids
by chromatography and countercurrent distribution. | [References]
Potesilova, Hrbek, Santavy, Collect. Czech. Chem. Commun., 32, 141 (1967)
Trudykulov, Yusupov, Sadykov, Khim. Prir. Soedin., 8,247 (1972)
Yusupov, Tr. Tashkent Fan., Uzbek SSR, 20, 24 (1972) |
|
| Company Name: |
Spectrum Chemical Manufacturing Corp.
|
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021-021-021-67601398-809-809-809 15221380277 |
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www.spectrumchemical.com/oa_html/index.jsp?minisite=10020&respid=22372&language=us |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Shureli Biopharma Co.,Ltd
|
| Tel: |
0871-68355600 18787766125 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList1143315/0_EN.htm |
| Company Name: |
Carbosynth
|
| Tel: |
+86 512 6260 5585 |
| Website: |
www.carbosynth.com |
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