| Identification | Back Directory | [Name]
aspergillomarasmine A | [CAS]
3484-65-9 | [Synonyms]
aspergillomarasmine A
Toxin C (Pyrenophora teres)
L-Aspartic acid, N-[(2S)-2-[[(2S)-2-amino-2-carboxyethyl]amino]-2-carboxyethyl]- | [Molecular Formula]
C10H17N3O8 | [MDL Number]
MFCD01664829 | [MOL File]
3484-65-9.mol | [Molecular Weight]
307.26 |
| Hazard Information | Back Directory | [Uses]
Aspergillomarasmine A is a natural aminopolycarboxylic acid with potent inhibitory activity against class B metallo-β-lactamases (MBLs). Aspergillomarasmine A inactivates MBLs by removing a catalytic Zn2+ cofactor. Aspergillomarasmine A acts as a selective Zn2+ scavenger, promoting the dissociation of the metal cofactor, thereby indirectly inactivating NDM-1. Aspergillomarasmine A causes the loss of Zn2+ ions from the low-affinity binding site of NDM-1. The action of Aspergillomarasmine A results in the rapid degradation of Zn2+-deficient NDM-1, thereby enhancing its potency as a β-lactam enhancer. The mechanism of Aspergillomarasmine A has broad applicability among different Zn2+ chelators[1]. | [Definition]
ChEBI: Aspergillomarasmine A is an aspartic acid derivative. | [References]
[1] Aspergillomarasmine A inhibits metallo-β-lactamases by selectively sequestering Zn2 |
|
|