| Identification | Back Directory | [Name]
1-BROMO-2-ETHYL-4-METHOXY-BENZENE | [CAS]
34881-44-2 | [Synonyms]
4-Bromo-3-ethylanisole
4-bromo-3-ethyl-1-methoxybezene
1-BROMO-2-ETHYL-4-METHOXY-BENZENE
Benzene, 1-bromo-2-ethyl-4-methoxy- | [Molecular Formula]
C9H11BrO | [MOL File]
34881-44-2.mol | [Molecular Weight]
215.09 |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 1-bromo-2-ethyl-4-methoxybenzene from 1-ethyl-3-methoxybenzene: 3-ethylanisole (50 g, 0.3676 mol) and N-bromosuccinimide (72 g, 0.4 mol) were dissolved in acetonitrile (1 L), and the reaction was stirred for 8 hours at room temperature protected from light. After completion of the reaction, the reaction mixture was concentrated at a temperature below 40 °C. The concentrated residue was redissolved in carbon tetrachloride and filtered to remove insoluble material. The filtrate was concentrated and finally the target product was obtained by fractional purification. A light yellow liquid product of 35 g was obtained in 43% yield. | [References]
[1] Bulletin of the Chemical Society of Japan, 1989, vol. 62, # 2, p. 591 - 593
[2] Patent: US2006/4222, 2006, A1. Location in patent: Page/Page column 1; 3; 5
[3] Journal of Medicinal Chemistry, 2009, vol. 52, # 23, p. 7788 - 7799 |
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| Company Name: |
BePharm Ltd
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| Tel: |
400-685-9117 |
| Website: |
www.bepharm.com |
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