| Identification | Back Directory | [Name]
7ALPHA-HYDROXYCHOLESTEROL-25,26,26,26,27,27,27-D7 | [CAS]
349553-94-2 | [Synonyms]
Cholesterol Impurity 37
7α-hydroxy Cholesterol-d7
cholest-5-en-3,7α-diol-d7
7alpha-hydroxycholesterol-d7
7α-Hydroxycholesterol-25?26?26?26?27?27?27-[d7]
7ALPHA-HYDROXYCHOLESTEROL-25,26,26,26,27,27,27-D7
CHOLEST-5-EN-3,7Α-DIOL-D7;7Α-HYDROXYCHOLESTEROL-D7 | [Molecular Formula]
C26H37D7O2 | [MDL Number]
MFCD01317395 | [MOL File]
349553-94-2.mol | [Molecular Weight]
395.67 |
| Hazard Information | Back Directory | [Description]
7α-hydroxy Cholesterol-d7 is intended for use as an internal standard for the quantification of 7α-hydroxy cholesterol by GC- or LC-MS. 7α-hydroxy Cholesterol is an oxysterol and a precursor in the biosynthesis of the bile acids cholic acid (CA; ) and chenodeoxycholic acid (CDCA; ). It is formed via the oxidation of cholesterol by cholesterol 7α-hydroxylase/CYP7A1 in rat liver microsomes. 7α-hydroxy Cholesterol (40 μM) increases levels of the adhesion molecules ICAM-1, VCAM-1, and E-selectin in human umbilical vein endothelial cells (HUVECs). It increases secretion of chemokine (C-C motif) ligand 2 (CCL2) and matrix metalloproteinase-9 (MMP-9) in serum-deprived THP-1 cells when used at a concentration of 5 μg/ml. 7α-hydroxy Cholesterol has been found in macrophages isolated from atherosclerotic lesions in rabbits fed a high-cholesterol diet. | [Uses]
7α-hydroxycholesterol-d7 has been used as an internal standard for cholesterol and oxysterol measurement by gas chromatography-mass spectrometry (GC/MS). | [General Description]
7α-hydroxycholesterol is an oxysterol synthesized by the oxidation of the side chain of cholesterol. It is the precursor of bile acid. | [storage]
Store at -20°C |
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