| Identification | Back Directory | [Name]
AC-IEPD-CHO | [CAS]
352520-90-2 | [Synonyms]
AC-IEPD-CHO
AC-ILE-GLU-PRO-ASP-CHO
GRANZYME B INHIBITOR IV
CASPASE-8 INHIBITOR III
N-Acetyl-Ile-Glu-Pro-Asp-al
AC-ILE-GLU-PRO-ASP-ALDEHYDE
AC-ILE-GLU-PRO-ASP-ALDEHYDE (PSEUDO ACID) | [Molecular Formula]
C22H34N4O9 | [MDL Number]
MFCD02259689 | [MOL File]
352520-90-2.mol | [Molecular Weight]
498.53 |
| Hazard Information | Back Directory | [Uses]
Ac-IEPD-CHO is a reversible granzyme B inhibitor with a Ki of 80 nM[1]. Ac-IEPD-CHO is also a caspase-8 inhibitor[2]. | [Biological Activity]
Cell permeable: no''Primary Target
granzyme B''Product does not compete with ATP.''Reversible: yes | [References]
[1] Mi-Sun Kim, et al. Approaches to design non-covalent inhibitors for human granzyme B (hGrB). Org Biomol Chem. 2014 Nov 28;12(44):8952-65. DOI:10.1039/c4ob01874e
[2] In-Sun Hong, et al. Gonadotropin-releasing hormones I and II induce apoptosis in human granulosa cells. J Clin Endocrinol Metab. 2008 Aug;93(8):3179-85. DOI:10.1210/jc.2008-0127
[3] Jamann H, et al. Contact-Dependent Granzyme B-Mediated Cytotoxicity of Th17-Polarized Cells Toward Human Oligodendrocytes. Front Immunol. 2022 Apr 11;13:850616. DOI:10.3389/fimmu.2022.850616 |
|
|