| Identification | Back Directory | [Name]
[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-1,3-propanedioicaciddimethylester | [CAS]
353280-43-0 | [Synonyms]
S26948
S26948,S-26948
S 26948 >=98% (HPLC)
[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-1,3-propanedioicaciddimethylester
2-[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-propanedioic acid 1,3-dimethyl ester
Propanedioic acid, 2-[[4-[2-(6-benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-, 1,3-dimethyl ester | [Molecular Formula]
C28H25NO7S | [MDL Number]
MFCD18086885 | [MOL File]
353280-43-0.mol | [Molecular Weight]
519.57 |
| Chemical Properties | Back Directory | [Melting point ]
65-67 °C(Solv: methanol (67-56-1)) | [Boiling point ]
687.3±65.0 °C(Predicted) | [density ]
1.312±0.06 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
DMSO: soluble10mg/mL (clear solution) | [form ]
powder | [pka]
12.48±0.59(Predicted) | [color ]
white to beige | [InChI]
1S/C28H25NO7S/c1-34-26(31)22(27(32)35-2)16-18-8-11-21(12-9-18)36-15-14-29-23-13-10-20(17-24(23)37-28(29)33)25(30)19-6-4-3-5-7-19/h3-13,17,22H,14-16H2,1-2H3 | [InChIKey]
NSMJEHGOMXSLCW-UHFFFAOYSA-N | [SMILES]
COC(=O)C(Cc1ccc(OCCN2C(=O)Sc3cc(ccc23)C(=O)c4ccccc4)cc1)C(=O)OC |
| Hazard Information | Back Directory | [Description]
S26948 is a peroxisome proliferator-activated receptor γ (PPARγ) agonist (EC50 = 8.83 nM in a transactivation assay). It is selective for PPARγ over PPARα, PPARβ/δ, and retinoid X receptor α (RXRα) at 10 μM. S26948 (30 mg/kg per day) decreases serum levels of glucose, triglycerides, non-esterified fatty acids, and insulin and increases hepatic palmitate oxidation in an ob/ob mouse model of type 2 diabetes. It decreases plasma levels of triglycerides and total and non-HDL cholesterol and the surface area of atherosclerotic lesions in the aortic sinus in an E2-KI transgenic mouse model of dyslipidemia and atherosclerosis fed a Western diet when administered at a dose of 30 mg/kg. | [Uses]
S26948 is a peroxisome proliferator-activated receptor γ modulator with potent antidiabetes and antiatherogenic effects. | [References]
[1] MARIA CARMEN CARMONA. S 26948: a new specific peroxisome proliferator activated receptor gamma modulator with potent antidiabetes and antiatherogenic effects.[J]. Diabetes, 2007, 56 11: 2797-2808. DOI: 10.2337/db06-1734 |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|