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35380-71-3

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35380-71-3 Structure

35380-71-3 Structure
IdentificationBack Directory
[Name]

Estradiol hemihydrate
[CAS]

35380-71-3
[Synonyms]

EESTRADIOL HEMIHYDRATE
Estradiol Hemihydrates
beta-Estradiol semihydrate
BETA-OESTRADIOL VETRANAL, 250 MG
Estra-1,3,5(10)-triene-3,17-diol(17b)-, hydrate (2:1)
(8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol,hydrate
[EINECS(EC#)]

631-198-2
[Molecular Formula]

C18H24O2.H2O
[MDL Number]

MFCD23102821
[MOL File]

35380-71-3.mol
[Molecular Weight]

290.4
Questions And AnswerBack Directory
[Uses]

Estradiol hemihydrate is a useful research chemical compound.
Chemical PropertiesBack Directory
[storage temp. ]

2-8°C
[form ]

neat
[BRN ]

1914275
[Major Application]

pharmaceutical
pharmaceutical small molecule
[InChI]

InChI=1/C18H24O2.H2O/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20;/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3;1H2/t14?,15-,16?,17-,18+;/s3
[InChIKey]

QJNCGXGNKJUDEM-KEFFNRLXNA-N
[SMILES]

C12CC[C@@H](O)[C@@]1(C)CCC1C3C=CC(O)=CC=3CC[C@@]21[H].O |&1:3,5,19,r|
Safety DataBack Directory
[Symbol(GHS) ]

Health Hazard (GHS08)Environment (GHS09)
GHS08,GHS09
[Signal word ]

Danger
[Hazard statements ]

H351-H360FD-H362-H410
[Precautionary statements ]

P202-P260-P263-P264-P273-P308+P313
[Hazard Codes ]

T
[Risk Statements ]

60-63-40-64
[Safety Statements ]

53-36/37-45
[WGK Germany ]

3
[HS Code ]

2937230000
[Storage Class]

6.1D - Non-combustible acute toxic Cat.3
toxic hazardous materials or hazardous materials causing chronic effects
[Hazard Classifications]

Aquatic Acute 1
Aquatic Chronic 1
Carc. 2
Lact.
Repr. 1A
Hazard InformationBack Directory
[in vivo]

Estradiol hemihydrate (1 nM, the hippocampal slices from FBN-ARO-KO mice) rescues long-term potentiation (LTP) amplitude[1]. Estradiol hemihydrate (0.0167 mg, implanted s.c., FBN-ARO-KO mice) rescues the molecular and functional deficits in FBN-ARO-KO mice[1].

Animal Model:FBN-ARO-KO Mice[2]
Dosage:1 nM
Administration:Treated for the hippocampal slices
Result:Rescued long-term potentiation (LTP) amplitude of both male and female mice.
Animal Model:FBN-ARO-KO Mice[2]
Dosage:0.0167 mg
Administration:Alzet minipumps with Estradiol (implanted s.c.), examined 7 days after minipump implantation.
Result:Restored hippocampal and cortical E2 levels to 93%, phosphorylation of AKT, ERK and CREB in the hippocampus and cortex to 90-95%, BDNF level to 80-90%, restored both synaptophysin and PSD95 in the forebrain. Rescued the spatial learning and memory defects.
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