| Identification | Back Directory | [Name]
cyamemazine | [CAS]
3546-03-0 | [Synonyms]
RP-7204
TH-2602
Tercian
7204 RP
Cianatil
CiaMatil
CyaMeMazin
7204 R. E.
F. I. 6229
cyamemazine
Cyamepromazine
CyaMeproMezine
Kyamepromazine
2-Cyano-10-(3-diMethylaMino-2-Methylpropyl)phenothiazine
10-[3-(dimethylamino)-2-methylpropyl]phenothiazine-2-carbonitrile
10-[3-(dimethylamino)-2-methyl-propyl]phenothiazine-2-carbonitrile
10-[3-(DiMethylaMino)-2-Methylpropyl]-10H-phenothiazine-2-carbonitrile
10H-Phenothiazine-2-carbonitrile, 10-[3-(dimethylamino)-2-methylpropyl]- | [EINECS(EC#)]
222-594-2 | [Molecular Formula]
C19H21N3S | [MDL Number]
MFCD00868180 | [MOL File]
3546-03-0.mol | [Molecular Weight]
323.46 |
| Chemical Properties | Back Directory | [Melting point ]
90-95°C | [Boiling point ]
bp0.2-0.5 205-220° | [density ]
1.21±0.1 g/cm3(Predicted) | [storage temp. ]
Refrigerator | [solubility ]
DMSO: ≥5mg/mL | [form ]
powder | [pka]
9.31±0.28(Predicted) | [color ]
light yellow to yellow-green | [InChI]
1S/C19H21N3S/c1-14(12-21(2)3)13-22-16-6-4-5-7-18(16)23-19-9-8-15(11-20)10-17(19)22/h4-10,14H,12-13H2,1-3H3 | [InChIKey]
SLFGIOIONGJGRT-UHFFFAOYSA-N | [SMILES]
CC(CN(C)C)CN1c2ccccc2Sc3ccc(cc13)C#N |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,N | [Risk Statements ]
50 | [Safety Statements ]
61 | [RIDADR ]
UN 3077 9 / PGIII | [WGK Germany ]
3 | [REACH Registrations]
Active | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Aquatic Acute 1
Aquatic Chronic 1 | [Toxicity]
LDLo oral in man: 107mg/kg |
| Hazard Information | Back Directory | [Chemical Properties]
Greenish Yellow Solid | [Originator]
Terckian,Theraplix,France,1972 | [Uses]
Cyamemazine is an anxiolytic antipsychotic, which reduces ethanol withdrawal symptoms. | [Definition]
ChEBI: Cyamemazine is a member of phenothiazines. | [Manufacturing Process]
The following is taken from US Patent 3,057,851. Milorganite was extracted
with water to obtain an aqueous extract containing vitamin B12 active
substances. This aqueous extract was purified by treatment with an ion
exchange resin according to the following method. An aqueous extract of
milorganite, 100 ml containing 300 μg of vitamin B12 active substances and
4.5 grams of total solids, was combined with 0.5 gram of sodium nitrite and
0.4 gram of potassium cyanide. The resulting solution was adjusted to pH 4.0
with hydrochloric acid and heated to boiling. The boiled solution was filtered
through a Super-Cel filter surface, and the filter was then washed with water.
The filtrate was obtained in a total volume of 130 ml including the washings.
Amerlite XE-97, an ion exchange resin of the carboxyl type (Rohm and Haas),
was classified to an average wet particle size of 100 to 150 mesh. The
classified resin was utilized in the hydrogen form, and was not buffered during
the ion exchange fractionation. The classified resin, in the amount of 35 ml,
was packed into a glass column having a diameter of 25 mm and a height of
250 mm. The cyanide-treated aqueous extract of milorganite was infused
gravitationally into the ion exchange bed at a rate of 3 ml per minute.
The effluent was discarded and the resin bed was then washed with the
following solutions in the specified sequence: (1) 120 ml of an aqueous 0.1 N
hydrochloric acid solution; (2) 75 ml of an aqueous 85% acetone solution;
and (3) 70 ml of an aqueous 0.1 N hydrochloric acid solution. After washing,
the resin bed was eluted with an aqueous 60% dioxane solution containing
0.1 N of hydrochloric acid. In this elution, 8 ml of colored eluate was
collected. This portion of the eluate was found to contain 295 μg of
cyanocobalamin and 9 mg of total solids. | [Therapeutic Function]
Tranquilizer | [Biological Activity]
Cyamemazine belongs to the class of phenothiazine drugs. It is known to tre at severe depressionschizophrenia and bipolar disorder.''Cyamemazine is a potent antagonist of 5-HT2C and 5-HT3 receptors with antipsychotic and anxiolytic properties. |
|
| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Shaanxi Dideu Medichem Co. Ltd
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| Telephone: |
+86-029-81138252 +86-173 9270 1263 |
| Website: |
https://www.chemicalbook.com/manufacturer/shaanxi-dideu-medichem-222/ |
| Company Name: |
Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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cjbscvictory
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13348960310 13348960310 |
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www.weikeqi-biotech.com/ |
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