| Identification | Back Directory | [Name]
1-(2-Methoxyethyl)-2-Methyl-4,9-dioxo-3-(pyrazin-2-ylMethyl)-4,9-dihydro-1H-naphtho[2,3-d]iMidazol-3-iuM chloride | [CAS]
355406-09-6 | [Synonyms]
YM-155 HCl
YM155 hydrochloride
YM 155 hydrochloride
YM-155 (hydrochloride)
YM155 HYDROCHLORIDE;YM 155 HYDROCHLORIDE
1-(2-Methoxyethyl)-2-Methyl-4,9-dioxo-3-(pyrazin-2-ylMethyl)-4,9-dihydro-1H-naphtho[2,3-d]iMidazol-3-iuM chloride | [Molecular Formula]
C20H19ClN4O3 | [MDL Number]
MFCD18207200 | [MOL File]
355406-09-6.mol | [Molecular Weight]
398.85 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
≥19.45 mg/mL in DMSO; ≥4.34 mg/mL in EtOH with gentle warming and ultrasonic; ≥48.1 mg/mL in H2O with ultrasonic | [form ]
solid | [color ]
Light brown to brown |
| Hazard Information | Back Directory | [Uses]
Sepantronium hydrochloride (YM-155 hydrochloride) is a novel survivin suppressant with an IC50 of 0.54 nM for the inhibition of survivin promoter activity[1]. | [in vivo]
Sepantronium bromide (YM155; 3 and 10 mg/kg) inhibits the tumor growth in PC-3 xenografts, without obvious body weight loss and blood cell count decrease. Sepantronium bromide is highly distributed to tumor tissue in vivo. Sepantronium bromide shows 80% TGI at a dose of 5 mg/kg in PC-3 orthotopic xenografts[1].
Sepantronium bromide (YM155) in combination with γ-radiation shows potent antitumor activity against H460 or Calu6 xenografts in nude mice[2].
In this orthotopic renal and metastatic lung tumors models, Sepantronium bromide (YM-155) and IL-2 additively decreases tumor weight, lung metastasis, and luciferin-stained tumor images[3]. | [target]
survivin | [References]
[1] Nakahara T, et al. YM155, a novel small-molecule survivin suppressant, induces regression of established human hormone-refractory prostate tumor xenografts. Cancer Res. 2007 Sep 1;67(17):8014-21. DOI:10.1158/0008-5472.CAN-07-1343
[2] Iisa T, et al. Radiosensitizing effect of YM155, a novel small-molecule survivin suppressant, in non-small cell lung cancer cell lines. Clin Cancer Res. 2008 Oct 15;14(20):6496-504. DOI:10.1158/1078-0432.CCR-08-0468
[3] Guo K, et al. A combination of YM-155, a small molecule survivin inhibitor, and IL-2 potently suppresses renal cell carcinoma in murine model. Oncotarget. 2015 Aug 28;6(25):21137-47. DOI:10.18632/oncotarget.4121 |
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| Company Name: |
SPIRO PHARMA
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| Telephone: |
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| Website: |
www.spiropharma.com.cn |
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