| Identification | Back Directory | [Name]
STK393606 | [CAS]
355827-05-3 | [Synonyms]
STK393606
2-(6-Bromo-3H-imidazo[4,5-b]pyridin-2-ylsulfanylmethyl)-benzonitrile
2-[(6-bromo-1H-imidazo[4,5-b]pyridin-2-yl)sulfanylmethyl]benzonitrile | [Molecular Formula]
C14H9BrN4S | [MDL Number]
MFCD02314298 | [MOL File]
355827-05-3.mol | [Molecular Weight]
345.22 |
| Hazard Information | Back Directory | [Description]
15-hydroxy prostaglandin dehydrogenase (15-hydroxy PGDH) is a key enzyme involved in the inactivation of PGs and related eiscosanoids. It functions by catalyzing the oxidation of primary PGs to their 15-keto metabolites. Two types of 15-hydroxy PGDH have been identified: type-I is NAD+-dependent primarily using eicosanoids as substrates, while type-II uses either NAD+ or NADP+ as cofactors and bears broader substrate specificity. STK393606 is a competitive inhibitor of NAD+-dependent type-I 15-hydroxy PGDH with an IC50 value of 26.4 nM and a Ki value of 5 nM. It demonstrates selectivity for 15-hydroxy PGDH when profiled across a panel of related dehydrogenase or reductase enzymes. | [Definition]
ChEBI: 2-[[(6-bromo-1H-imidazo[4,5-b]pyridin-2-yl)thio]methyl]benzonitrile is an imidazopyridine. | [target]
nad+-dependent type-i 15-hydroxy pgdh | [IC 50]
26.4 nm | [References]
[1] niesen f h, schultz l, jadhav a, et al. high-affinity inhibitors of human nad + -dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships[j]. plos one, 2010, 5(11).
[2] tai h, ensor c m, tong m, et al. prostaglandin catabolizing enzymes.[j]. prostaglandins & other lipid mediators, 2002: 483-493.
[3] lee s c, levine l. prostaglandin metabolism. ii. identification of two 15-hydroxyprostaglandin dehydrogenase types.[j]. journal of biological chemistry, 1975, 250(2): 548-552. |
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