| Identification | Back Directory | [Name]
Diethylaminoethyl | [CAS]
3563-01-7 | [Synonyms]
aprofen
APROPHEN
Aprofenum
Diethylaminoethyl
2,2-Diphenylpropionic acid 2-diethylaminoethyl ester
2,2-Diphenylpropionic acid 2-(diethylamino)ethyl ester
α-Methyl-α-phenylphenylacetic acid 2-(diethylamino)ethyl ester
Benzeneacetic acid, α-methyl-α-phenyl-, 2-(diethylamino)ethyl ester | [Molecular Formula]
C21H27NO2 | [MDL Number]
MFCD00242790 | [MOL File]
3563-01-7.mol | [Molecular Weight]
325.44 |
| Hazard Information | Back Directory | [Originator]
Aprofene,ZYF Pharm Chemical | [Uses]
Aprophen (Aprofene) is an antimuscarinic inhibitor. Aprophen can be used for the research of central nervous system[1]. | [Manufacturing Process]
32 parts of α,α-diphenylpropionic acid chloride (made from diphenylpropionic
acid and thionyl chloride, B.P./12 mm 170°C) are mixed with 50 parts of
diethylaminoethanol. The mixture is heated for two hours to 150°-160°C. It is
then suspended in dilute hydrochloric acid. The solution is treated with ether.
After separation of the aqueous solution, the base is precipitated with sodium
hydroxide solution and suspended in ether.
After removal of the ether by distillation, the residue is distilled in a vacuum.
α,α-Diphenylpropionic acid β-diethylaminoethyl ester is obtained as a thick oil
by distilling under 2 mm pressure at 180°-185°C. It is readily soluble in
diluted acids. | [Therapeutic Function]
Spasmolytic | [References]
[1] A comparison of the antimuscarinic properties of aprophen with those of some other anticholinergic drugs. Issue: MRL-R-794. Pages: 10 pp. Report 1980. |
|
|