| Identification | Back Directory | [Name]
4-[2-(3-Bromophenyl)ethenyl]-6-(trifluoromethyl)-2(1H)-pyrimidinone | [CAS]
357158-20-4 | [Synonyms]
BVFP
4-[2-(3-Bromophenyl)ethenyl]-6-(trifluoromethyl)-2(1H)-pyrimidinone | [Molecular Formula]
C13H8BrF3N2O | [MOL File]
357158-20-4.mol | [Molecular Weight]
345.11 |
| Chemical Properties | Back Directory | [density ]
1.58±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [form ]
Solid | [pka]
6.34±0.10(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
BVFP binds to the PGRN588–593 peptide with a Kd of 20 μM. BVFP can disrupt PGRN-SORT1 binding. BVFP also inhibits SORT1-mediated rPGRN endocytosis[1]. | [References]
[1] Lee WC, et al. Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency. Hum Mol Genet. 2014 Mar 15;23(6):1467-78. DOI:10.1093/hmg/ddt534 |
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