| Identification | Back Directory | [Name]
N.41 | [CAS]
357441-99-7 | [Synonyms]
VifA3G Inhibitor N.41
Vif-A3G Inhibitor N.41
Vif-A3G Inhibitor-N.41
2-Buten-1-one, 3-[(4-hydroxyphenyl)amino]-1-(3-pyridinyl)- | [Molecular Formula]
C15H14N2O2 | [MOL File]
357441-99-7.mol | [Molecular Weight]
254.28 |
| Hazard Information | Back Directory | [Description]
Vif-A3G Inhibitor N.41 is a HIV-1 inhibitor-targeting drug that causes Vif-dependent degradation of human APOBEC3G, thereby inhibiting the Vif-A3G interaction. | [Uses]
N.41 is an antiviral agent. N.41 protects APOBEC3G (an antiviral factor) from HIV Vif protein-mediated degradation. N.41 inhibits the Vif-A3G interaction and increases cellular A3G levels and incorporation of A3G into virions, thereby attenuating virus infectivity in a Vif-dependent manner. N.41 inhibits HIV-1 viral replication in PBMCs (IC50: 8.4 μM)[1]. | [References]
[1] Pery E, et al. Identification of a novel HIV-1 inhibitor targeting Vif-dependent degradation of human APOBEC3G protein. J Biol Chem. 2015 Apr 17;290(16):10504-17. DOI:10.1074/jbc.M114.626903 |
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