| Identification | Back Directory | [Name]
N-[(4S)-4-AMINO-5-[(2-AMINOETHYL]AMINO]P | [CAS]
357965-99-2 | [Synonyms]
NOS1-IN-1
NOS-1-IN-1,NOS1 IN 1,NOS1IN1
N-[(4S)-4-AMINO-5-[(2-AMINOETHYL]AMINO]P
Nitric Oxide Synthase, Neuronal Inhibitor I
Nitric Oxide Synthase, Neuronal Inhibitor I - CAS 357965-99-2
Nitric Oxide Synthase, Neuronal Inhibitor I - CAS 357965-99-2 - Calbiochem | [Molecular Formula]
C8H21N7O2.3C2HF3O2 | [MDL Number]
MFCD05865227 | [MOL File]
357965-99-2.mol | [Molecular Weight]
589.367 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
H2O: 50 mg/mL, soluble | [form ]
powder | [color ]
White to off-white | [Water Solubility ]
water: 1mg/mL | [InChI]
1S/C8H21N7O2.3C2HF3O2/c9-3-5-12-6-7(10)2-1-4-13-8(11)14-15(16)17;3*3-2(4,5)1(6)7/h7,12H,1-6,9-10H2,(H3,11,13,14);3*(H,6,7)/t7-;;;/m0.../s1 | [InChIKey]
NYWNMNBIORWOSQ-QTPLPEIMSA-N | [SMILES]
FC(F)(F)C(=O)O.FC(F)(F)C(=O)O.FC(F)(F)C(=O)O.[N+](=O)(N\C(=N\CCC[C@H](N)CNCCN)\N)[O-] |
| Hazard Information | Back Directory | [Uses]
NOS1-IN-1 is a selective and cell-permeable nNOS inhibitor with a Ki of 120 nM. NOS1-IN-1 exhibits 2617-fold and 325-fold selectivity over eNOS (Ki=39 μM) and iNOS (Ki=325 μM) , respectively[1]. NOS1-IN-1 can be used for the research of neurological disease, including cerebral palsy (CP)[2]. | [Biological Activity]
Cell permeable: yes''Primary Target
nNOS''Product does not compete with ATP.''Reversible: no''Target Ki: 120 nM against nNOS | [IC 50]
nNOS: 120 nM (Ki) | [storage]
Store at -20°C | [References]
[1] J M Hah, et al. Reduced amide bond peptidomimetics. (4S)-N-(4-amino-5-[aminoakyl]aminopentyl)-N'-nitroguanidines, potent and highly selective inhibitors of neuronal nitric oxide synthase. J Med Chem. 2001 Aug 2;44(16):2667-70. DOI:10.1021/jm0101491
[2] Haitao Ji, et al. Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy. Ann Neurol. 2009 Feb;65(2):209-17. DOI:10.1002/ana.21555 |
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BOC Sciences
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https://www.bocsci.com |
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Merck Millipore
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1-400-889-1988 400-889-1988 |
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http://www.merckmillipore.com |
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Merck KGaA
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