| Identification | Back Directory | [Name]
dianemycin | [CAS]
35865-33-9 | [Synonyms]
Nsc138320
dianemycin
Nanchangmycin free acid
Nanchangmycin >=98% (HPLC)
6-Nonenoic acid, 8-[(2S,2'R,4'S,5R,5'S,7R,7'R,8R,9S,9'S,10'R)-9-hydroxy-2,4',8,10'-tetramethyl-2'-[(2S,3S,5R,6R)-tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-9'-[[(2S,5S,6R)-tetrahydro-5-methoxy-6-methyl-2H-pyran-2-yl]oxy][2,7'-bi-1,6-dioxaspiro[4.5]dec]-7-yl]-2,4,6-trimethyl-5... | [Molecular Formula]
C47H78O14 | [MOL File]
35865-33-9.mol | [Molecular Weight]
867.11 |
| Chemical Properties | Back Directory | [Boiling point ]
700.37°C (rough estimate) | [density ]
1.0559 (rough estimate) | [refractive index ]
1.6130 (estimate) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 155 mg/mL (178.75 mM); Water: < 0.1 mg/mL (insoluble) | [form ]
Solid | [pka]
4.59±0.21(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Dianemycin (Nanchangmycin free acid), a polyether antibiotic produced by Streptomyces nanchangensis NS3226, inhibits gram-positive bacteria[1]. Nanchangmycin is a broad spectrum antiviral active against Zika virus[2]. | [Biological Activity]
Dianemycin (Nanchangmycin free acid) is a polyether antibiotic produced by Streptomyces nanchangensis NS3226, which inhibits Gram-positive bacteria. It is also a broad-spectrum antiviral drug against Zika virus. | [in vitro]
Dianemycin (Nanchangmycin) can be used as a growth promotant in poultry and to cure coccidiosis in chickens. It is active against drug resistant strains of malaria. | [target]
| [storage]
Store at -20°C | [References]
[1] Liu T, et al. Mechanism of thioesterase-catalyzed chain release in the biosynthesis of the polyether antibiotic Nanchangmycin. Chem Biol. 2008 May;15(5):449-58. DOI:10.1016/j.chembiol.2008.04.006
[2] Rausch K, et al. Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus. Cell Rep. 2017 Jan 17;18(3):804-815. DOI:10.1016/j.celrep.2016.12.068 |
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