| Identification | Back Directory | [Name]
3'-SIALYLLACTOSE | [CAS]
35890-38-1 | [Synonyms]
3'-SL（GM3）
Sialyl-D-lactose
osyl-(1.fwdarw.4)-
GM3 Ganglioside sugar
Sia--2, 3-Gal--1,4-Glc
3'-SIALYLLACTOSE USP/EP/BP
n-acetylneuraminoyllactose
NANA-Lactose, Sialyl-D-lactose
3)-O-b-D-galactopyranosyl-(1®
α-neunac-(2→3)-β-d-gal-(1→4)-d-glc
3'-SIALYLLACTOSE, FROM BOVINE MILK O
GM3 Ganglioside sugar / 3'Sialyllactose
3'-N-acetylneuraminyl-lactose, sodium salt
3′-N-Acetylneuraminyl-D-lactose sodium salt
3'-N-ACETYLNEURAMINYL-LACTOSEFROM HUMAN MILK
D-Glucose, O-(N-acetyl-a-neuraMinosyl)-(2®
3'-N-ACETYLNEURAMINYL-LACTOSE SODIUMFROM BOVINE CO
3-O-(N-Acetyl-α-neuraminosyl)-4-O-(β-D-galactopyranosyl)-D-glucose
N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucose
D-Glucose, O-(N-acetyl-α-neuraminosyl)-(2→3)-O-β-D-galactopyranosyl-(1→4)-
d-glucose,o-(n-acetyl-alpha-neuraminosyl)-(2.fwdarw.3)-o-beta-d-galactopyran
D-Glucose, O-(N-acetyl-.alpha.-neuraminosyl)-(2?3)-O-.beta.-D-galactopyranosyl-(1?4)-
Neu5Ac-a-2-3-Gal-b-1-4-Glc,GM3 trisaccharide sodium salt,3’-N-Acetylneuraminyl-D-lactose sodium salt
3μ-N-Acetylneuraminyl-D-lactose sodium salt, 3μ-Sialyl-D-lactose, 3μ-SL, NANA-Lactose, α-NeuNAc-(2-3)-β-D-Gal-(1-4)-D-Glc
(2S,4S,5R,6R)-5-acetamido-2-[(2R,3S,4S,5R,6R)-3,5-dihydroxy-2-(hydroxymethyl)-6-[(2R,3R,4R,5R)-1,2,4,5-tetrahydroxy-6-oxo-hexan-3-yl]oxy-oxan-4-yl]oxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid
(2S,4S,5R,6R)-5-Acetamido-2-(((2R,3S,4S,5R,6S)-3,5-dihydroxy-2-(hydroxymethyl)-6-(((2R,3R,4R,5R)-1,2,4,5-tetrahydroxy-6-oxohexan-3-yl)oxy)tetrahydro-2H-pyran-4-yl)oxy)-4-hydroxy-6-((1R,2R)-1,2,3-trihydroxypropyl)tetrahydro-2H-pyran-2-carboxylic acid | [Molecular Formula]
C23H39NO19 | [MDL Number]
MFCD00168068 | [MOL File]
35890-38-1.mol | [Molecular Weight]
633.55 |
| Chemical Properties | Back Directory | [Boiling point ]
1132.8±65.0 °C(Predicted) | [density ]
1.72±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C | [solubility ]
water: 20 mg/mL, clear, colorless | [form ]
powder | [pka]
1.92±0.70(Predicted) | [color ]
white | [biological source]
bovine milk or colostrum | [Water Solubility ]
water: 20mg/mL, clear, colorless | [BRN ]
75357 | [Cosmetics Ingredients Functions]
SKIN CONDITIONING | [InChIKey]
LTWFUJWFLMHANB-TZCPRLTCSA-M | [SMILES]
[Na+].[H]C(=O)[C@H](O)[C@@H](O)[C@H](O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O[C@@]2(C[C@H](O)[C@@H](NC(C)=O)[C@@H](O2)[C@H](O)[C@H](O)CO)C([O-])=O)[C@H]1O)[C@H](O)CO | [EPA Substance Registry System]
D-Glucose, O-(N-acetyl-.alpha.-neuraminosyl)-(2.fwdarw.3)-O-.beta.-D-galactopyranosyl-(1.fwdarw.4)- (35890-38-1) |
| Hazard Information | Back Directory | [Uses]
3′-Sialyllactose is a compound where in the acetylneuraminyl (NANA) unit is connected to the galactosyl unit of lactose at the 3 position. In 6′-sialylactose, this connection is at the 6 position. 3′-Sialyllactose and 6′-Sialyllactose are used to differentiate and characterize binding domains of viruses, such as influenza and rhinitis viruses, that recognize NANA capped cell surface receptors. 3′-Sialyllactose and 6′-sialylactose are used as reference compounds in analytical methods developed to measure their presence in materials such as milk and colostrums. | [in vivo]
3'-Sialyllactose (10-100 mg/kg; p.o. three times a week for 6 weeks) protects mice against cartilage destruction from osteoarthritis[1].
3'-Sialyllactose (500, 1000 and 2000 mg/kg; orally administration; once) induces no micronuclei in the bone marrow cells of mice[3].
3'-Sialyllactose (oral administration; (500 to 1000 to 2000 mg/kg) every dose at 4-day intervals) shows the maximum tolerance dose (MTD) is greater than 2000 mg/kg in male and female beagle dogs[3].
3'-Sialyllactose shows a lethal dose (LD50) above 20 g/kg bw, the highest dose tested[3]. | Animal Model: | 8-week-old male C57BL/6 mice with medial meniscus surgery[1] | | Dosage: | 10, 50 and 100 mg/kg | | Administration: | Oral gavage; 10-100 mg/kg three times a week; for 6 weeks | | Result: | Effectively protected osteoarthritis mice against cartilage destruction by catabolic factor expression. |
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