| Identification | Back Directory | [Name]
(1R,2R)-B13 | [CAS]
35922-06-6 | [Synonyms]
D-NMAPPD
CAY10466
(1R,2R)-B13
D-NMAPPD Exclusive
N-[(1R,2R)-2-HYDROXY-1-(HYDROXYMETHYL)-2-(4-NITROPHENYL)ETHYL]-TETRADECANAMIDE
Tetradecanamide, N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]- | [Molecular Formula]
C23H38N2O5 | [MDL Number]
MFCD08062172 | [MOL File]
35922-06-6.mol | [Molecular Weight]
422.56 |
| Chemical Properties | Back Directory | [Boiling point ]
636.2±55.0 °C(Predicted) | [density ]
1.101±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2)(1:2): .3 mg/ml | [form ]
A crystalline solid | [pka]
12.72±0.20(Predicted) | [color ]
white to beige | [Optical Rotation]
[α]/D -28 to -34, c =0.1 in chloroform-d | [InChI]
1S/C23H38N2O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-22(27)24-21(18-26)23(28)19-14-16-20(17-15-19)25(29)30/h14-17,21,23,26,28H,2-13,18H2,1H3,(H,24,27)/t21-,23-/m1/s1 | [InChIKey]
XUSDVLHKNBOGJY-FYYLOGMGSA-N | [SMILES]
[N+](=O)([O-])c1ccc(cc1)[C@@H](O)[C@H](NC(=O)CCCCCCCCCCCCC)CO |
| Hazard Information | Back Directory | [Uses]
D-NMAPPD is d-NMAPPD is a potent Acid Ceramidase inhibitor that induces apoptosis.. | [Biological Activity]
D-NMAPPD (B13)a myristoyl-CoA analogis a cell penetrant inhibitor of N-myristoyltransferases th at suppressed FRS2α (fibroblast growth factor receptor substrate 2) myristoylation. D-NMAPPD inhibits wild-type FGFRs and drug-resistant mutants (FGFRsDRM) oncogenic signaling in cancer cells. D-NMAPPD potently inhibits growth of xenograft tumors in mice. D-NMAPPD is a potent inhibitor of ceramidase th at elevates endogenous ceramide levels and suppress growth of cancer cells. |
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| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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