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360-63-4

360-63-4 Structure

360-63-4 Structure
IdentificationBack Directory
[Name]

Dexamethasone sodium phosphate EP Impurity B
[CAS]

360-63-4
[Synonyms]

Unii-yjo1F9W10r
Einecs 206-636-7
Betamethasone phosphate
Betamethasone 21-phosphate
Betamethasone 21-phopsphate
Dexamethasone Impurity B(EP)
Betamethasone dihydrogen phosphate
Betamethasone 21-(dihydrogen phosphate)
Betamethasone-4,6,11,12,12-d5 21-Phosphate
9-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-phosphate
9-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-phosphoric acid
(11β,16β)-9-Fluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4 -dien-21-yl dihydrogen phosphate
9-fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 21-(hydrogen phosphonate)
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, (11beta,16beta)-
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, (11β,16β)- (9CI)
Pregna-1,4-diene-3,20-dione, 9-fluoro-11-beta,17,21-trihydroxy-16-beta-methyl-, 21-(dihydrogen phosphate)
Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16β-methyl-, 21-(dihydrogen phosphate) (7CI, 8CI)
Betamethasone phosphateQ: What is Betamethasone phosphate Q: What is the CAS Number of Betamethasone phosphate
Betamethasone Phosphate-D4Q: What is Betamethasone Phosphate-D4 Q: What is the CAS Number of Betamethasone Phosphate-D4
[EINECS(EC#)]

206-636-7
[Molecular Formula]

C22H30FO8P
[MDL Number]

MFCD01698987
[MOL File]

360-63-4.mol
[Molecular Weight]

472.44
Safety DataBack Directory
[Symbol(GHS) ]

Health Hazard (GHS08)Environment (GHS09)
GHS08,GHS09
[Signal word ]

Danger
[Hazard statements ]

H410-H372-H360
[Precautionary statements ]

P260-P264-P270-P314-P501-P273-P391-P501
Hazard InformationBack Directory
[Originator]

Bentelan,Biofutura
[Uses]

Glucocorticoid.
[Definition]

ChEBI: Betamethasone phosphate is a steroid phosphate that is the 21-O-phospho derivative of betamethasone. It has a role as an anti-inflammatory agent and an immunosuppressive agent. It is a steroid phosphate, an 11beta-hydroxy steroid, a fluorinated steroid, a 17alpha-hydroxy steroid, a 20-oxo steroid, a 3-oxo-Delta(1),Delta(4)-steroid and a tertiary alpha-hydroxy ketone. It is functionally related to a betamethasone. It is a conjugate acid of a betamethasone phosphate(2-).
[Manufacturing Process]

A solution of bistriethylamine phosphate was prepared by slowly adding 2.36 ml of 85% phosphoric acid to 20 ml of acetonitrile containing 9.9 ml, of triethylamine at 20°C. This solution was added to a stirred mixture of 4.70 g of 9α-fluoro-11β,17α,21-trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione 21-methanesulfonate and 20 ml of acetonitrile. The mixture was heated under reflux for 4 h and then evaporated under reduced pressure to a volume of 12 ml. This mixture was a concentrated solution of 9α-fluoro-11β,17α,21- trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione 21-phosphate triethylamine salt with some inorganic phosphate.
The salt of 9α-fluoro-11β,17α,21-trihydroxy-16α-methyl-1,4-pregnadiene- 3,20-dione 21-phosphate may be converted to 9α-fluoro-11β,17α,21- trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione 21-phosphate by treatment with acid (for example HCl).
[Brand name]

Celestone (Schering).
[Therapeutic Function]

Glucocorticoid
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