| Identification | Back Directory | [Name]
5-[(2-nitrophenyl)methylidene]thiazolidine-2,4-dione | [CAS]
36140-65-5 | [Synonyms]
NSC 55655
5-[Methylidene]thiazolidine-2,4-dione
2,4-Thiazolidinedione, 5-[(2-nitrophenyl)methylene]-
5-[(2-nitrophenyl)methylidene]thiazolidine-2,4-dione
5-[(2-Nitrophenyl)methylidene]-1，3-thiazolidine-2，4-dione | [Molecular Formula]
C10H6N2O4S | [MDL Number]
MFCD08681906 | [MOL File]
36140-65-5.mol | [Molecular Weight]
250.23 |
| Hazard Information | Back Directory | [Uses]
5-[(2-Nitrophenyl)methylene]-2,4-thiazolidinedione (Compound 4) has antimicrobial, anti-diabetic and antioxidant activities. 5-[(2-Nitrophenyl)methylene]-2,4-thiazolidinedione inhibits B. subtilis, S. aureus, K. pneumonia, E. coli, and S. typhi with MICs of 4.5-9.9 μΜ/mL, and inhibits A. niger and C. albicans with MICs of 4.99 μΜ/mL[1]. | [References]
[1] Elkamhawy A, et al. Thiazolidine-2,4-dione-based irreversible allosteric IKK-β kinase inhibitors: Optimization into in vivo active anti-inflammatory agents. Eur J Med Chem. 2020 Feb 15;188:111955. DOI:10.1016/j.ejmech.2019.111955 |
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