| Identification | Back Directory | [Name]
Phosphorylcholine | [CAS]
3616-04-4 | [Synonyms]
Phosphorylcholine (Phosphocholine) | [Molecular Formula]
C5H15NO4P+ | [MDL Number]
MFCD32689427 | [MOL File]
3616-04-4.mol | [Molecular Weight]
184.15 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at 4°C | [solubility ]
Water: 100 mg/mL (546.03 mM); Ethanol: 4 mg/mL (21.84 mM); DMSO: < 1 mg/mL (insoluble or slightly soluble) | [form ]
Oil | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
Phosphatidylcholine is the main phospholipid component in eukaryotic biofilms. Phosphatidylcholine exists in commensal or pathogenic bacteria associated with eukaryotes in prokaryotes. Phosphorylcholine exhibits a surprising range of immunomodulatory properties[1]. | [Definition]
ChEBI: Phosphocholine is the phosphate of choline; and the parent compound of the phosphocholine family. It has a role as an epitope, a hapten, a human metabolite, a mouse metabolite and an allergen. It is a conjugate acid of a choline phosphate(1-). | [in vivo]
Phosphorylcholine (200-600 μmol/kg; ip; single dose) activates nicotinic and muscarinic cholinergic neurotransmission, stimulates the activation of α2-adrenergic receptors, and increases plasma glucagon and choline concentrations, thereby stimulating peripheral autonomic nervous system activity[3].
Phosphorylcholine (2 μg; ip; once every two weeks for 4 months) induces the production of anti-PC and anti-oxLDL antibodies, increases mature B cells in the spleen, and reduces atherosclerotic lesions in the aortic root in mouse models[4].
| Animal Model: | Sprague Dawley rats model[3] | | Dosage: | 200-600 μmol/kg | | Administration: | ip; single dose | | Result: | Increased plasma glucagon and choline concentration. |
| Animal Model: | apoE knockout mouse model[4] | | Dosage: | 2 μg | | Administration: | ip; once every two weeks for 4 months | | Result: | Induced anti-PC and anti-oxLDL antibodies, reduced atherosclerotic lesions. |
| [IC 50]
Human Endogenous Metabolite; Microbial Metabolite | [storage]
Store at 4°C | [References]
[1] Harnett W, et al. Phosphorylcholine: friend or foe of the immune system? Immunol Today. 1999 Mar;20(3):125-9. DOI:10.1016/s0167-5699(98)01419-4
[2] Tu S, et al., Enhancement of cellular uptake and antitumor efficiencies of micelles with phosphorylcholine. Macromol Biosci. 2011 Oct 10;11(10):1416-25. DOI:10.1002/mabi.201100111
[3] Cansev M, et al., Choline, CDP-choline or phosphocholine increases plasma glucagon in rats: involvement of the peripheral autonomic nervous system. Eur J Pharmacol. 2008 Jul 28;589(1-3):315-22. DOI:10.1016/j.ejphar.2008.05.017
[4] Caligiuri G, et al., Phosphorylcholine-targeting immunization reduces atherosclerosis. J Am Coll Cardiol. 2007 Aug 7;50(6):540-6. DOI:10.1016/j.jacc.2006.11.054 |
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Rhawn Reagent
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| Company Name: |
MedChemExpress
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