| Identification | Back Directory | [Name]
3H-Indolium, 2-[5-(1,3-dihydro-3,3-dimethyl-1-octadecyl-2H-indol-2-ylidene)-1,3-pentadien-1-yl]-3,3-dimethyl-1-octadecyl-, 4-chlorobenzenesulfonate (1:1) | [CAS]
362596-00-7 | [Synonyms]
Did (cell membrane red fluorescent probe)
3H-Indolium, 2-[5-(1,3-dihydro-3,3-dimethyl-1-octadecyl-2H-indol-2-ylidene)-1,3-pentadien-1-yl]-3,3-dimethyl-1-octadecyl-, 4-chlorobenzenesulfonate (1:1) | [Molecular Formula]
C67H103ClN2O3S | [MOL File]
362596-00-7.mol | [Molecular Weight]
1052.08 |
| Hazard Information | Back Directory | [Description]
DiD is a lipophilic fluorescent probe.1 It is rapidly incorporated into phospholipid cell membranes and has been used to label the plasma membrane and endocytic organelles in bovine aorta endothelial cells and rat hippocampal slices.1,2,3 DiD has also been used to assess proliferation in prostate cancer cell lines by flow cytometry, where high DiD-expressing cell populations are associated with lower proliferation.1 DiD is not cytotoxic and can be detected in subcutaneously implanted PC3 cells in vivo after three weeks. It displays absorption/emission maxima of 650/670 nm, respectively.4WARNING This product is not for human or veterinary use. | [References]
[1] KENJI YUMOTO. A novel method for monitoring tumor proliferation in vivo using fluorescent dye DiD[J]. Cytometry Part A, 2014, 85 6: 548-555. DOI: 10.1002/cyto.a.22434
[2] MICHAEL E. DAILEY Marc W. Confocal Imaging of Microglial Cell Dynamics in Hippocampal Slice Cultures[J]. Methods, 1999, 18 2: Pages 222-230. DOI: 10.1006/meth.1999.0775
[3] CHARLES P. LIN Irene E K Mary C Lynch. Reactive Oxidizing Species Produced near the Plasma Membrane Induce Apoptosis in Bovine Aorta Endothelial Cells[J]. Experimental cell research, 2000, 259 2: Pages 351-359. DOI: 10.1006/excr.2000.4979
[4] TÂNIA RIBEIRO. NIR and visible perylenediimide-silica nanoparticles for laser scanning bioimaging[J]. Dyes and Pigments, 2014, 110: Pages 227-234. DOI: 10.1016/j.dyepig.2014.03.026 |
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