| Identification | Back Directory | [Name]
4-Methylhistamine dihydrochloride | [CAS]
36376-47-3 | [Synonyms]
SKF-71517
4-Methylhistamine di
4-Methylhistamine DiHCl
4-Methylhistamine (hydrochloride)
4-METHYLHISTAMINE DIHYDROCHLORIDE
5-Methylhistamine dihydrochloride
Methylhistamine dihydrochloride, 4-
2-(4-methyl-1H-imidazol-5-yl)ethanamine
4-(2-Aminoethyl)-5-methylimidazole dihydrochloride
5-Methyl-1H-imidazole-4-ethanamine dihydrochloride
5-(2-AMINOETHYL)-4-METHYLIMIDAZOLE DIHYDROCHLORIDE
2-(5-Methyl-4-imidazolyl)ethylamine dihydrochloride
Imidazole, 4-(2-aminoethyl)-5-methyl-, dihydrochloride
2-(4-methyl-1H-imidazol-5-yl)ethanamine dihydrochloride
2-(5-Methyl-1H-iMidazol-4-yl)ethanaMine dihydrochloride
1H-Imidazole-4-ethanamine, 5-methyl-, dihydrochloride (9ci) | [Molecular Formula]
C6H14Cl2N3 | [MDL Number]
MFCD01721796 | [MOL File]
36376-47-3.mol | [Molecular Weight]
199.101 |
| Chemical Properties | Back Directory | [Melting point ]
231-233℃ (ethanol ) | [storage temp. ]
Desiccate at RT | [solubility ]
DMSO (Slightly, Heated), Methanol (Slightly) | [form ]
Solid | [color ]
White to Pale Beige | [Water Solubility ]
Soluble to 50 mM in water |
| Hazard Information | Back Directory | [Description]
4-Methylhistamine (dihydrochloride) is the potent agonist of histamine 4 receptor (H4R). 4-Methylhistamine (dihydrochloride) has the potential for the research of immune-related diseases such as cancer and autoimmune disorders. | [Uses]
Histamine H2 receptor agonist, antagonist and antineoplastic agent on the in vitro growth of peripheral blood CFU-GM from normal individuals and HL-60 leukemia cells. | [Biological Activity]
4-Methylhistamine dihydrochloride is a potent, high affinity H4 receptor agonist (Ki = 7 nM) that displays > 100-fold selectivity over other human histamine receptor subtypes. | [storage]
Desiccate at RT | [References]
[1]. lim hd, van rijn rm, ling p, et al. evaluation of histamine h1-, h2-, and h3-receptor ligands at the human histamine h4 receptor: identification of 4-methylhistamine as the first potent and selective h4 receptor agonist. journal of pharmacology and experimental therapeutics, 2005, 314(3): 1310-1321.
[2]. ahmad sf, ansari ma, zoheir kma, et al. regulation of tnf-α and nf-κb activation through the jak/stat signaling pathway downstream of histamine 4 receptor in a rat model of lps-induced joint inflammation. immunobiology, 2015, 220(7): 889-898. |
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