| Identification | Back Directory | [Name]
L-HOMOCARNOSINE FREE BASE | [CAS]
3650-73-5 | [Synonyms]
NSC92522
NSC-92522
NSC 92522
γAbu-L-His-OH
L-HOMOCARNOSINE FREE BASE
γ-Aminobutyryl-L-histidine
Nα-(4-Aminobutyryl)histidine
N-(4-amino-1-oxobutyl)-L-Histidine
L-Histidine, N-(4-aMino-1-oxobutyl)- | [Molecular Formula]
C10H16N4O3 | [MDL Number]
MFCD00035202 | [MOL File]
3650-73-5.mol | [Molecular Weight]
240.26 |
| Chemical Properties | Back Directory | [Boiling point ]
646.9±55.0 °C(Predicted) | [density ]
1.327±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMF: 30 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 10 mg/ml | [form ]
A solid | [pka]
2.99±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
Homocarnosine is a dipeptide of γ-aminobutyric acid (GABA) and histidine unique to brain. Homocarnosine is an inhibitory neuromodulator synthesized in the neuron from GABA and exhibiting anticonvulsant effects[1].Homocarnosine has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition of advanced glycation end-product formation[2]. | [Definition]
ChEBI: A homocarnosine that has S configuration. | [IC 50]
Human Endogenous Metabolite | [storage]
Store at -20°C | [References]
[1] O A Petroff, et al. Vigabatrin increases human brain homocarnosine and improves seizure control. Ann Neurol. 1998 Dec;44(6):948-52. DOI:10.1002/ana.410440614
[2] Thanutchaporn Kumrungsee, et al. Dietary GABA induces endogenous synthesis of a novel imidazole peptide homocarnosine in mouse skeletal muscles. Amino Acids. 2020 May;52(5):743-753. DOI:10.1007/s00726-020-02848-x |
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Alfa Chemistry
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https://www.alfa-chemistry.com |
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