| Identification | Back Directory | [Name]
ZORUBICIN HCL | [CAS]
36508-71-1 | [Synonyms]
rubidaz
22050r.p.
nsc-164011
ZORUBICIN HCL
rp22,050hydrochloride
rubidazone,monohydrochloride
daunorubicin,benzoylhydrazone,monohydrochloride
benzoicacidhydrazide,3-hydrazonewithdaunorubicin,monohydrochloride
(2S-cis)-Benzoic acid[1-[4-[(3-amino-2，3，6-trideoxy-α-L-lyxo-hex-opyranosyl)oxy]-1，2，3，4，6，11-hexahydro-2，5，12-trihydroxy-7-methoxy-6，11-dioxo-2-napthacenyl]ethylidene]hydrazide hydroehloride
Benzoic acid, 1-(2S,4S)-4-(3-amino-2,3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyl)oxy-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenylethylidenehydrazide, monohydrochloride
Benzoic acid, [1-[4-[(3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]ethylidene]hydrazide, monohydrochloride, (2S-cis)- | [EINECS(EC#)]
253-076-4 | [Molecular Formula]
C34H36ClN3O10 | [MDL Number]
MFCD00941450 | [MOL File]
36508-71-1.mol | [Molecular Weight]
682.12 |
| Chemical Properties | Back Directory | [alpha ]
D20 -50° (c = 0.2 in water) | [solubility ]
DMSO (Slightly), Methanol (Slightly), Water (Slightly) | [form ]
Solid | [color ]
Orange to Dark Red | [Stability:]
Light Sensitive |
| Hazard Information | Back Directory | [Chemical Properties]
Obtained as an orange-red crystalline powder from ethanol. [α]D 20-50° (C = 0.2, water). UV absorption maxima (methanol): 232.5, 253, 480, 495 nm (ε 40225, 35300, 10480, 10300). Acute toxicity LD50 in mice (mg/kg): 13.66 subcutaneously, 4.42 intraperitoneally, and 8.50 intravenously. | [Originator]
Zorubicin
Hydrochloride,ZYF Pharm
Chemical | [Uses]
Antineoplastic. | [Uses]
Zorubicin Hydrochloride is an anthracycline anti-cancer drug related to Daunorubicin (D194500). | [Manufacturing Process]
9.024 g daunorubicin-hydrochloride (its preparation and physicochemical
properties have been described in British Patent Specification No 985 598)
was dissolved in 800 ml ethanol and mixed with 2.5 ml acetic acid and 2.162
g benzoyl hydrazide and heated for 24 hours at 60°C. On cooling the obtained
precipitate was filtered off, washed with 100 ml of ethanol and dried in
vacuum at 20°C. It was dissolved in water and small quantity of insoluble
product was filtered off, the filtrate was lyophilized. (1-(4-((3-Amino-2,3,6-
trideoxy-α,L-lyxohexopyranosyl)oxy)-1,2,3,4,6,11-hexahydro-2,5,12-
trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl)ethylidene)hydrazide
dihydrochloride (zorubicin) was obtained as red-orange crystalline powder;
[α] D 20 = -50° (c=0.2 in water). The compound may be employed in the form
of different non-toxic salts such as benzoates, fumarates, maleates, tartrates
and so on. The best among these compounds proves to be daunorubicin
benzoylhydrazone (rubidazone), which is less cardiotoxic (French Pat. No.
1,578,722 published in 1967, Class CO7d). | [Therapeutic Function]
Antineoplastic, Antileukemic |
|
| Company Name: |
Energy Chemical
|
| Telephone: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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