| Identification | Back Directory | [Name]
Benzamide, 5-chloro-N-(5-chloro-2-pyridinyl)-2-[[4-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)benzoyl]amino]-3-hydroxy- | [CAS]
365462-61-9 | [Synonyms]
AS1468240 AS-1468240 AS 1468240 Benzamide, 5-chloro-N-(5-chloro-2-pyridinyl)-2-[[4-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)benzoyl]amino]-3-hydroxy- | [Molecular Formula]
C25H25Cl2N5O3 | [MOL File]
365462-61-9.mol | [Molecular Weight]
514.4 |
| Hazard Information | Back Directory | [Description]
AS1468240 is a factor Xa inhibitor with significant oral anticoagulant activity. | [Uses]
AS1468240 is an orally active inhibitor for anticoagulant factor Xa (fXa), that inhibits human fXa with IC50 of 8.7 nM. AS1468240 prolongs the coagulation time in mice[1]. | [References]
[1] Ishihara T, et al., Identification of potent orally active factor Xa inhibitors based on conjugation strategy and application of predictable fragment recommender system. Bioorg Med Chem. 2015 Jan 15;23(2):277-89. DOI:10.1016/j.bmc.2014.11.042 |
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