| Identification | Back Directory | [Name]
1H-Isoindol-1-one,2,3-dihydro-4-methoxy-(9CI) | [CAS]
366453-22-7 | [Synonyms]
4-Methoxy-2,3-dihydro-isoindol-1-one
2,3-Dihydro-4-methoxy-1H-isoindol-1-one
4-Methoxy-2,3-dihydro-1H-isoindol-1-one
1H-Isoindol-1-one, 2,3-dihydro-4-Methoxy-
1H-Isoindol-1-one,2,3-dihydro-4-methoxy-(9CI) | [Molecular Formula]
C9H9NO2 | [MDL Number]
MFCD09701287 | [MOL File]
366453-22-7.mol | [Molecular Weight]
163.17 |
| Chemical Properties | Back Directory | [Melting point ]
>200 °C | [Boiling point ]
439.2±45.0 °C(Predicted) | [density ]
1.208±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [pka]
14.37±0.20(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
Step b: A mixed solution of methyl 2-bromomethyl-3-methoxybenzoate (997 mg, 3.85 mmol) and ammonium hydroxide (9 mL) in THF (19 mL) was reacted with stirring at room temperature for 4 hours. After completion of the reaction, the reaction mixture was concentrated to dryness under reduced pressure. The resulting residue was purified by fast column chromatography (eluent: hexane/ethyl acetate, 40/60 with 1% methanol) to afford 4-methoxyisoindolin-1-one as a white solid (595 mg, 95% yield). | [References]
[1] Chinese Chemical Letters, 2012, vol. 23, # 1, p. 9 - 12
[2] Patent: WO2004/26875, 2004, A1. Location in patent: Page 38
[3] Patent: US2004/106791, 2004, A1. Location in patent: Page 9
[4] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 2, p. 814 - 819 |
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Tetranov Biopharm
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