| Identification | Back Directory | [Name]
MRS 2279 | [CAS]
367909-40-8 | [Synonyms]
MRS 2279
MRS2279,MRS-2279
MRS 2279, CID: 5311301
[(1S,2R,4R)-4-[(2-chloro-6-methylaminopurin-9-yl)methyl]-2-(phosphonooxymethyl)cyclopentyl] dihydrogen phosphate
Bicyclo[3.1.0]hexane-1-methanol, 4-[2-chloro-6-(methylamino)-9H-purin-9-yl]-2-(phosphonooxy)-, 1-(dihydrogen phosphate), (1R,2S,4S,5S)-
(1R*,2S*)-4-[2-Chloro-6-(methylamino)-9H-purin-9-yl]-2-(phosphonooxy)bicyclo[3.1.0]hexane-1-methanoldihydrogenphosphateesterdiammoniumsalt | [Molecular Formula]
C13H18ClN5O8P2 | [MDL Number]
MFCD09038551 | [MOL File]
367909-40-8.mol | [Molecular Weight]
469.71 |
| Hazard Information | Back Directory | [Uses]
MRS 2279 is a selective P2Y1 antagonist with high affinity and results in modulation of aggregation of blood platelets induced by ADP. | [Biological Activity]
Selective, high affinity competitive antagonist of the P2Y 1 receptor (K i = 2.5 nM; IC 50 = 51.6 nM). Fails to block nucleotide signaling at most other P2Y receptors (P2Y 2 , P2Y 4 , P2Y 6 , P2Y 11 and P2Y 12 ) and potently inhibits ADP-induced aggregation of human blood platelets in vitro (pK B = 8.05). | [in vivo]
MRS2279 (2 μL, 1 nM; intracerebroventricular injection; 30 min prior to mechanical ventilation) reduces mouse brain injury induced by mechanical ventilation in high-pressure ventilation mice[3]. | [IC 50]
P2Y1 Receptor: 51.6 nM (IC50) |
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