| Identification | Back Directory | [Name]
2-ethylthioisonicotinamide monohydrochloride | [CAS]
3684-73-9 | [Synonyms]
Ethionamide HCl
Einecs 222-972-7
Ethionamide hydrochloride
2-ethylthioisonicotinamide monohydrochloride | [EINECS(EC#)]
222-972-7 | [Molecular Formula]
C8H11ClN2S | [MOL File]
3684-73-9.mol | [Molecular Weight]
202.704 |
| Hazard Information | Back Directory | [Description]
Ethionamide HCl is the salt form of Ethionamide, a second-line antitubercular agent that inhibits mycolic acid synthesis. Ethionamide is a nicotinamide derivative, with antibacterial activity, used to treat tuberculosis. Although the exact mechanism of action of ethionamide is unknown, it may inhibit the synthesis of mycolic acid, a saturated fatty acid found in the bacterial cell wall, thereby inhibiting bacterial cell wall synthesis. This eventually leads to bacterial cell wall disruption and cell lysis. Ethionamide may be bacteriostatic or bactericidal in action, depending on the concentration of the drug at the site of infection and the susceptibility of the organism involved. It binds with NAD+ to form an adduct. | [Uses]
Ethionamide hydrochloride (2-Ethylthioisonicotinamide hydrochloride) is an antituberculosis drug with mycobacterial activity. Ethionamide hydrochloride interferes with the bacterial cell wall synthesis process by inhibiting the synthesis of fatty acids in the bacterial cell wall. Ethionamide hydrochloride may have bacteriostatic or bactericidal effects, depending on the concentration of the drug at the site of infection and the susceptibility of the associated microorganisms. Ethionamide hydrochloride combines with NAD+ to form an adduct, thereby exerting its antibacterial effect[1]. | [References]
[1] Ethionamide-induced acneiform drug eruption in a patient with multiresistant tuberculosis DOI:10.1111/ajd.13817 |
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