| Identification | Back Directory | [Name]
1-HYDROXYMETHYL-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTER | [CAS]
3697-68-5 | [Synonyms]
Ethyl 1-(hydroxymethyl)
1,1 Cyclopropane dicarboxylic acid ethyl ester
Ethyl1-(hydroxymethyl)cyclopropanecarboxylate,97%
ethyl 1-(hydroxymethyl)cyclopropane-1-carboxylate
Ethyl 1-(hydroxyMethyl)cyclopropanecarboxylate, 97%
1-HYDROXYMETHYL-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTER
Cyclopropanecarboxylic acid, 1-(hydroxyMethyl)-, ethyl ester | [Molecular Formula]
C7H12O3 | [MDL Number]
MFCD09759206 | [MOL File]
3697-68-5.mol | [Molecular Weight]
144.17 |
| Chemical Properties | Back Directory | [Boiling point ]
90-94 °C(Press: 8 Torr) | [density ]
1.159±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [pka]
15.10±0.10(Predicted) | [Appearance]
Colorless to light yellow Liquid | [InChI]
InChI=1S/C7H12O3/c1-2-10-6(9)7(5-8)3-4-7/h8H,2-5H2,1H3 | [InChIKey]
PAILVKQSHRJIPE-UHFFFAOYSA-N | [SMILES]
C1(CO)(C(OCC)=O)CC1 | [CAS DataBase Reference]
3697-68-5 |
| Hazard Information | Back Directory | [Uses]
Ethyl 1-(hydroxymethyl)cyclopropanecarboxylate acts as a ligand for Suzuki coupling reaction. | [Synthesis]
Example 64 Preparation of ethyl 1-(hydroxymethyl)cyclopropanecarboxylate
A tetrahydrofuran solution of 1 M tri-tert-butoxy lithium aluminum (70.90 mL, 70.90 mmol) was slowly added dropwise to a stirred solution of diethyl cyclopropane-1,1-dicarboxylate (6 g, 32.20 mmol) in tetrahydrofuran (129 mL). The reaction system was stirred at 23 °C and gradually warmed to 65 °C and maintained at this temperature for 24 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the reaction was quenched with 10% sodium bisulfate solution (275 mL) and subsequently extracted with ether. The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford the light yellow oily target product ethyl 1-(hydroxymethyl)cyclopropanecarboxylate (4.60 g, 91% yield). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 4.16 (q, J = 7 Hz, 2H), 3.62 (s, 2H), 2.60 (br s, 1H), 1.22-1.30 (m, 5H), 0.87 (dd, J = 7, 4 Hz, 2H). | [References]
[1] Patent: US2012/110702, 2012, A1. Location in patent: Page/Page column 38
[2] Patent: US2013/109566, 2013, A1. Location in patent: Paragraph 0400; 0401
[3] Patent: US2013/288893, 2013, A1. Location in patent: Paragraph 0450-0451
[4] Patent: US2016/60245, 2016, A1. Location in patent: Paragraph 0451; 0452
[5] Patent: US2012/53146, 2012, A1. Location in patent: Paragraph 0170; 0171 |
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