| Identification | Back Directory | [Name]
ALPHA-HYDROXYALPRAZOLAM | [CAS]
37115-43-8 | [Synonyms]
A-HYDROXYALPRAZOLAM
α-Hydroxyalprazolam
ALPHA-HYDROXYALPRAZOLAM
alpha-Hydroxyalprazolam solution
α-hydroxyalprazolam Solution, 100ppm
ALPHA-HYDROXYALPRAZOLAM,100/MLINMETHANOL
A-hydroxyalprazolam--dea schedule*iv item
ALPHA-HYDROXYALPRAZOLAM,1.0MG/MLINMETHANOL
ALPHA-HYDROXYALPRAZOLAM (100UG/ML METHANOL)
1-Hydroxy AlprazolaM (1.0 Mg/ML in Methanol)
ALPHA-HYDROXYALPRAZOLAM UNLABELED 1.0 MG/ML IN METHANOL
ALPHA-HYDROXYALPRAZOLAM UNLABELED 100 UG/ML IN METHANOL
ALPHA-HYDROXYALPRAZOLAM (D5, 98%) 100 UG/ML IN METHANOL
ALPHA-HYDROXYALPRAZOLAM (D5, 98%) 1000 UG/ML IN METHANOL
6-Phenyl-8-chloro-4H-s-triazolo[4,3-a]benzodiazepine-1-Methanol
4H-1,2,4Triazolo4,3-a1,4benzodiazepine-1-methanol, 8-chloro-6-phenyl-
8-Chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-1-methanol | [EINECS(EC#)]
200-659-6 | [Molecular Formula]
C17H13ClN4O | [MDL Number]
MFCD00171226 | [MOL File]
37115-43-8.mol | [Molecular Weight]
324.76 |
| Chemical Properties | Back Directory | [Appearance]
Yellow solid | [Melting point ]
129-134°C | [Fp ]
9℃ | [storage temp. ]
-20°C Freezer | [solubility ]
methylene chloride: ~20 mg/mL, clear, colorless to faintly yellow
| [form ]
powder
| [color ]
white to off-white
| [Major Application]
clinical testing | [InChI]
1S/C17H13ClN4O/c18-12-6-7-14-13(8-12)17(11-4-2-1-3-5-11)19-9-15-20-21-16(10-23)22(14)15/h1-8,23H,9-10H2 | [InChIKey]
ZURUZYHEEMDQBU-UHFFFAOYSA-N | [SMILES]
OCc1nnc2CN=C(c3ccccc3)c4cc(Cl)ccc4-n12 |
| Hazard Information | Back Directory | [Description]
α-hydroxy Alprazolam (Item No. 15287) is an analytical reference material categorized as a benzodiazepine. It is a major active metabolite of alprazolam (CRM) (Item No. ISO60185) that has a higher urinary recovery than 4-hydroxy alprazolam (Item No. 15878), another major metabolite.1,2,3 α-hydroxy Alprazolam has a lower binding affinity than alprazolam for the GABAA receptor.1 It is also a metabolite of adinazolam (Item No. 18205).4 This product is intended for research and forensic applications. | [Chemical Properties]
Yellow solid | [Uses]
A metabolite of Alprazolam, an anxiolytic | [Definition]
ChEBI: Alpha-Hydroxyalprazolam is a triazolobenzodiazepine. | [General Description]
A major urinary metabolite of the benzodiazepine alprazolam. Alprazolam, commonly sold under the trade name Xanax?, is a short-acting anxiolytic approved to treat panic and other anxiety disorders including generalized or social anxiety disorder. This certified Snap-N-Spike? solution standard is suitable for use in LC/MS or GC/MS applications such as forensic analysis, clinical toxicology, urine drug testing, or pain prescription monitoring. | [References]
[1] D J GREENBLATT C E W. Clinical pharmacokinetics of alprazolam. Therapeutic implications.[J]. Clinical Pharmacokinetics, 1993, 24 6: 453-471. DOI: 10.2165/00003088-199324060-00003
[2] MIOK SHIN. Screening of multiple drugs of abuse and metabolites in urine using LC/MS/MS with polarity switching electrospray ionization[J]. Archives of Pharmacal Research, 2013, 37 6: 760-772. DOI: 10.1007/s12272-013-0225-0
[3] ANNIKA ALLQVIST. Simultaneous quantification of alprazolam, 4- and α-hydroxyalprazolam in plasma samples using liquid chromatography mass spectrometry[J]. Journal of Chromatography B, 2005, 814 1: Pages 127-131. DOI: 10.1016/j.jchromb.2004.10.012
[4] A D FRASER W B A F Isner. Urinary screening for adinazolam and its major metabolites by the Emit d.a.u. and FPIA benzodiazepine assays with confirmation by HPLC.[J]. Journal of analytical toxicology, 1993, 17 7: 427-431. DOI: 10.1093/jat/17.7.427 |
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