| Identification | Back Directory | [Name]
1-(2,6-dimethyl-1H-indol-3-yl)-2-[4-(furan-2-carbonyl)piperazin-1-yl]ethanone | [CAS]
371210-26-3 | [Synonyms]
AMB639752
1-(2,6-dimethyl-1H-indol-3-yl)-2-[4-(furan-2-carbonyl)piperazin-1-yl]ethanone
Ethanone, 1-(2,6-dimethyl-1H-indol-3-yl)-2-[4-(2-furanylcarbonyl)-1-piperazinyl]- | [Molecular Formula]
C21H23N3O3 | [MOL File]
371210-26-3.mol | [Molecular Weight]
365.43 |
| Hazard Information | Back Directory | [Uses]
AMB639752 is a potent DGKα inhibitor. AMB639752 restores restimulation induced cell death (RICD) in SAP deficient lymphocytes by inhibiting DGKα in intact cells. AMB639752 can be used for X-linked lymphoproliferative disease 1(XLP-1) research[1]. | [References]
[1] Velnati S, et.al. Identification of a novel DGKα inhibitor for XLP-1 therapy by virtual screening. Eur J Med Chem. 2019 Feb 15;164:378-390. DOI:10.1016/j.ejmech.2018.12.061 |
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