| Identification | Back Directory | [Name]
YM348 | [CAS]
372163-84-3 | [Synonyms]
YM348
1H-Furo[2,3-g]indazole-1-ethanamine, 7-ethyl-α-methyl-, (αS)- | [Molecular Formula]
C14H17N3O | [MDL Number]
MFCD31630702 | [MOL File]
372163-84-3.mol | [Molecular Weight]
243.31 |
| Chemical Properties | Back Directory | [Boiling point ]
395.2±32.0 °C(Predicted) | [density ]
1.28±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Oil | [pka]
8.95±0.10(Predicted) | [color ]
Light yellow to brown |
| Hazard Information | Back Directory | [Uses]
YM348, is a potent and orally active 5-HT2C receptor agonist. | [in vivo]
Oral administration of YM348 induces penile erections and hypolocomotion in rats, being completely inhibited by a selective 5-HT2C receptor antagonist, SB242084. YM348 inhibits spontaneous activity in a dose-dependent manner with a minimum effective dose of 0.203 mg/kg[1]. | [IC 50]
5-HT2C Receptor: 0.89 nM (Ki); 5-HT2B Receptor: 2.5 nM (Ki); 5-HT2A Receptor: 13 nM (Ki); 5-HT2C Receptor: 1 nM (EC50); 5-HT2B Receptor: 3.2 nM (EC50); 5-HT2A Receptor: 93 nM (EC50) |
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| Company Name: |
MedChemExpress
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021-58955995 |
| Website: |
www.medchemexpress.com |
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